丙酸氟替卡松气雾剂或布地奈德混悬液干预对毛细支气管炎反复喘息的疗效观察

目的 比较丙酸氟替卡松气雾剂(辅舒酮)和布地奈德混悬液对毛细支气管炎再发喘息的疗效观察.方法 将初发毛细支气管炎患儿214 例随机分为辅舒酮组(106 例)和布地奈德组(108 例),分别在临床症状缓解后继续给予辅舒酮或布地奈德规律吸入.另选取临床症状缓解后未规律吸入激素的毛细支气管炎患儿136 例作为对照组.随访观察1 年.评估 2 种干预治疗对患儿反复咳喘发作的影响.结果 辅舒酮组和布地奈德组在1 年内的咳喘次数以及前3 个月的咳喘复发率均明显低于对照组(P<0.05),但两个治疗组之间差异无统计学意义(P>0.05).布地奈德组在激素用量和治疗花费方面高于辅舒酮组(P<0.01).结论 毛细支气管炎患儿临床症状缓解后继续给予辅舒酮或布地奈德规律吸入可减少咳喘发作和复发.辅舒酮在治疗费用和激素用量方面优于布地奈德.

Efficacy of fluticasone propionate aerosol versus budesonide suspension in treatment of recurrent wheezing caused by bronchiolitis

ObjectiveTo investigate the efifcacy of lfuticasone propionate aerosol (lfixotide) versus budesonide suspension in the treatment of recurrent wheezing caused by bronchiolitis.MethodsA total of 214 infants with newly diagnosed bronchiolitis were randomly divided into lfixotide treatment (106 infants) and budesonide treatment groups (108 infants), and were given aerosol inhalation of lfixotide or budesonide for 3 months after achieving remission of clinical symptoms. Another 136 infants with bronchiolitis who did not receive regular inhalation of corticosteroid after achieving remission of clinical symptoms were enrolled as the control group. The follow-up visits were performed for 1 year, and the effects of the two therapeutic methods on recurrent wheezing were evaluated.ResultsCompared with the control group, both the lfixotide and budesonide treatment groups had signiifcantly fewer times of wheezing episodes within 1 year and a signiifcantly lower recurrence rate of wheezing within the ifrst 3 months after regular inhalation of corticosteroid, but no significant differences were observed between the two treatment groups. The amount of corticosteroid inhaled and hospital costs in the budesonide treatment group were signiifcantly higher than in the lfixotide treatment group (P<0.01).ConclusionsContinuous inhalation of lfixotide or budesonide after remission of clinical symptoms in children with bronchiolitis can reduce wheezing episodes and the recurrence of wheezing, and lfixotide treatment is superior to budesonide treatment in the aspects of hospital costs and the amount of corticosteroid used.