四抗感冒口服液的抗病毒、抗菌及镇痛作用研究

目的　研究四抗感冒口服液 (CCD)的抗病毒、抗菌及镇痛作用。方法　应用病毒致细胞病变作用观察CCD的抗病毒作用 ;应用平皿挖洞灌药法观察CCD的抑菌作用 ;应用热诱发小鼠疼痛反应模型和冰醋酸诱导小鼠扭体反应模型观察CCD对疼痛的抑制作用。结果　CCD对疱疹病毒Ⅰ型的半数有效浓度为 0 98g·L-1。CCD 1 0 0g·ml-1对金葡菌(ATCC 2 5 92 3)、金葡菌 (MRSA)、表皮葡萄球菌、肺炎链球菌和草绿色链球菌均有抑制作用。CCD 5 0g·kg-1和 10 0g·kg-1可明显延长小鼠热痛反应潜伏期 (P <0 0 5 ,P <0 0 1) ,提高小鼠的痛阈值 ,且维持时间较阿司匹林长。CCD 10 0g·kg-1与 2 0 0g·kg-1对小鼠扭体反应次数有明显抑制作用 (P<0 0 1)。结论　CCD具有一定的体外抗病毒、抗菌作用 ;CCD具有镇痛作用 ,且作用维持时间较长。

Study on the anti-virus function,anti-bacteria function and analgesic effect of Sikang ganmao oral liquores

Aim To study the effects of Sikang ganmao oral liquores(CCD) on virus,bacteria and analgesia.Methods Virus induced cell pathological changes were used to observe the anti virus effect of CCD;the method of pouring drug into plate media holes was adopted to observe the anti bacteria effect CCD;and heat induced pain response and acetic acid induced writhing in mice were employed to observe the analgesic effect of CCD.Results The median effective concentration of CCD anti herpes virus Ⅰ was 0.98 g·L -1 .CDD 1 0 g·ml -1 showed inhibition against staphylococcus aureus(ATCC 25923,MRSA),epidermidis staphylococcus,streptococcus pneumoniae and streptococcus viridans CCD 5.0 and 10 0 g·kg -1 prolonged incubation period of hot plate reaction in mice(P<0 05,P<0 01).CCD 10 0 and 20 0 g·kg -1 showed marked suppressive effect on writhing induced by acetic acid in mice(P<0 01).Conclusion CCD has anti virus and bacteria function.It also possesses analgesic effect for a relatively long time.