| Caveolin与脑功能关系的研究进展 |
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| 引用本文： | 王璐,嵇志红,陈冬冬,王红霞,邹伟.Caveolin与脑功能关系的研究进展[J].生物化学与生物物理进展,2007,34(5):449-453. |
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| 作者姓名： | 王璐 嵇志红 陈冬冬 王红霞 邹伟 |
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| 作者单位： | 1. 辽宁师范大学生命科学学院,大连,116029
2. 大连大学医学院,大连,116622 |
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| 摘 要： | Caveolin作为细胞质膜微囊——Caveolae的标志蛋白,参与Caveolae的形成、定位,并具有介导膜泡运输、维持细胞胆固醇稳态和调控信号转导等功能.近年来发现,Caveolin与脑功能的生理或病理变化有关,在神经发育、突触可塑性以及神经退行性疾病中起着重要的作用.结合最新的研究进展和前期实验结果,简单介绍Caveolin的结构和功能,并对其在脑功能中的调控作用作一阐述与展望.
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| 关 键 词： | 神经发育 突触可塑性 神经退行性疾病 |
| 收稿时间： | 2006/11/14 0:00:00 |
| 修稿时间： | 2/6/2007 12:00:00 AM |
Progress of Caveolin and Its Role in Brain |
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| WANG Lu,JI Zhi-Hong,CHEN Dong-Dong,WANG Hong-Xia and ZOU Wei.Progress of Caveolin and Its Role in Brain[J].Progress In Biochemistry and Biophysics,2007,34(5):449-453. |
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| Authors: | WANG Lu JI Zhi-Hong CHEN Dong-Dong WANG Hong-Xia and ZOU Wei |
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| Affiliation: | College of Life Science, Liaoning Normal University, Dalian 116029, China;Medical School, Dalian University, Dalian 116622, China;College of Life Science, Liaoning Normal University, Dalian 116029, China;College of Life Science, Liaoning Normal University, Dalian 116029, China;College of Life Science, Liaoning Normal University, Dalian 116029, China |
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| Abstract: | Caveolins are a family of plasmalemmal vesicles caveolae-associated integral membrane proteins and a marker protein of caveolae involved in the formation and localization that associated with vesicular transport, cellular cholesterol homeostasis and signal transduction. Recent years, strong experimental evidences indicated that caveolins play a pivotal role in the brain function such as neural development, synaptic plasticity and neurodegenerative diseases. Recent progress on studies of the structure and functions of caveolins was simply summarized. The regulatory role of caveolins in the brain functions has been reviewed and expected. |
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| Keywords: | Caveolin |
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