有机阴离子转运蛋白在外源化学物毒性中的作用

机体接触各种潜在毒性有机阴离子,包括内源性物质如激素、神经递质和细胞代谢产物;外源性化学物质如多种药物、农药和动植物毒素等。快速有效地清除其中的毒性物质是机体最好的防御方式。有机阴离子转运蛋白介导的跨上皮主动转运通常是其中的限速过程。因此,研究有机阴离子转运蛋白的种类、分布及其转运与表达调控机制具有重要的毒理学意义。

Role of organic anion transporters in xenobiotics induced toxicity

It is unavoidable for body to exposure of organic anions including endogenous agents such as hormones, neurotransmitters and cellular metabolites, and xenobiotic agents such as medication, herbicides, pesticides, and plant and animal toxins. Rapid and efficient elimination of toxic substances among them is the body′s best defense. The active transepithelial transport mediated by organic anion transporters is often a rate limiting step. Therefore, the investigations of organic anion transporters about their classification, tissue distrubution driving force, gene expression and regulatory are of great significance in toxicology.