Computer-assisted mathematical analysis of sigmoid biological events |
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Authors: | Milzani, Aldo Carrera, Paolo Bergna, Giovanni Colombo, Roberto |
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Affiliation: | Department of Biology, Laboratory of Zoology and Cytology, University of Milan Via Celoria 26, 20133 Milan 1U I LD M (Unione Italiana Lotta alla Distrofia Muscolare) Via Lissoni 14, 20052 Monza (Milan), Italy |
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Abstract: | A program in BASIC is described which allows accurate quantificationof some numerical parameters that can be objectively correlatedto biological indexes in sigmoid biological events. Attentionwas focused on the polymerization process of actin (a muscleprotein with a mol. wt of 42 000 daltons) studied as the variationin the OD360 index with time. The experimental points, if plotted,can be well approximated by a rational function of the typeOD360 = f(t), which passes through the origin and can be representedgraphically by a sigmoid curve. The program was very helpfulin comparing the experimental curves and in analysing significantparameters, such as maximum velocity and asymptote, that characterizethese curves and whose interpretation would otherwise be purelysubjective. Received on July 11, 1985; accepted on January 13, 1986 |
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