脑靶向纳米载体系统的研究进展

目的:综述脑靶向纳米载体系统的研究进展。方法:收集相关最新发表的文献,对纳米载体给药系统透过血脑屏障对中构神经系统疾病的治疗进行分析总结。结果与结论:血脑屏障成为治疗神经系统疾病过程的一道难题,血脑屏障既可以保护大脑不受外界有害物质的侵害,维持脑部内环境的稳定,同时也限制了药物进入脑部发挥其治疗作用。随着纳米技术的发展,纳米药物载体系统(如脂质体,聚合物纳米粒,胶束,纳米凝胶,微乳和固体脂质纳米粒)的应用使药物的跨血脑屏障转运和脑内传递成为可能。这将该变脑部疾病的治疗策略。

Research Progress on Brain-targeted Nano-carrier Systems

Objective： To review the latest research progress on brain-targeted nano-carrier systems. Methods：Recent published literatures on brain-targeted nano-carrier systems for the treatment of central nervous system diseases were col ected, analyzed and summarized. Results and conclusion：The blood-brain barrier （BBB） is considered to be the major obstacle in treating central nervous system diseases. BBB can make brain far away from harmful substances and maintain the steady state of microenvironment of brain. Meanwhile BBB also gives rise to the poor penetration of drugs into brain. With the development of nanotechnology, the nanocarriers such as liposomes, nanoparticles, micel es, nanogel, microemulsion and solid lipid nanoparticles for delivering drugs make it possible to transport drugs across the BBB. Therefore, possible strategies for brain-targeting could be available.