| 灯盏花素磷脂复合物改善大鼠小肠吸收的研究 |
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| 引用本文： | 唐晓荞,杨祥良.灯盏花素磷脂复合物改善大鼠小肠吸收的研究[J].中国中药杂志,2005,30(3):222-225. |
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| 作者姓名： | 唐晓荞 杨祥良 |
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| 作者单位： | 1. 湖北省疾病预防控制中心,湖北,武汉,430079
2. 华中科技大学,生命科学与技术学院,湖北,武汉,430074 |
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| 摘 要： | 目的研究灯盏花素磷脂复合物对灯盏花素实验性小肠吸收的改善作用。方法采用大鼠在体小肠循环法和离体外翻肠囊法研究灯盏花素普通粉剂和灯盏花素磷脂复合物的小肠吸收及肠壁通透性。结果大鼠在体小肠吸收实验中,灯盏花素磷脂复合物单位吸收量和单位吸收率分别提高7375%和4711%,肠壁通透性增加7313%;离体小肠吸收实验中,灯盏花素磷脂复合物单位吸收量和单位吸收率分别提高4121%和30%,肠壁通透性增加3935%;在0～100μg·mL-1内,吸收符合Fick’s扩散定律,表现出一级动力学过程。结论灯盏花素磷脂复合物主要以被动扩散的方式吸收,并通过提高肠壁通透性来改善其吸收。
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| 关 键 词： | 灯盏花素 磷脂复合物 小肠吸收 在体循环 外翻肠囊法 |
| 文章编号： | 1001-5302(2005)03-0222-04 |
| 收稿时间： | 2004/5/20 0:00:00 |
Enhanced absorption of breviscapine photosomes in small intestine of rats |
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| TANG Xiao-qiao;YANG Xiang-liang.Enhanced absorption of breviscapine photosomes in small intestine of rats[J].China Journal of Chinese Materia Medica,2005,30(3):222-225. |
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| Authors: | TANG Xiao-qiao;YANG Xiang-liang |
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| Affiliation: | Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China. |
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| Abstract: | OBJECTIVE: To investigate whether the absorption of breviscapine can be enhanced by using breviscapine photosomes. METHOD: Testing the uptake and intestinal permeability of breviscapine powder and breviscapine photosomes by using intestine perfusion technique and reverted gut sac method. RESULT: The uptake and permeability coefficient of breviscapine were increased in photosomes. The absorption process obeyed the Fick's law in the range of 0-100 microg x mL(-1). CONCLUSION: The absorption breviscapine photosomes is enhanced by increasing the permeability through a passive mechanism. |
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| Keywords: | breviscapine photosomes intestine absorption intestine perfusion everted gut sac |
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