| ADP受体阻滞剂的研究进展 |
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| 引用本文： | 石方牛,徐为人,张士俊,王玉丽.ADP受体阻滞剂的研究进展[J].心血管病学进展,2007,28(1):130-133. |
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| 作者姓名： | 石方牛 徐为人 张士俊 王玉丽 |
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| 作者单位： | 1. 天津医科大学,天津,300070;天津药物研究院,天津,300193
2. 天津药物研究院,天津,300193 |
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| 摘 要： | ADP受体阻滞剂是一类与血小板的ADP受体特异性结合从而抑制血栓形成的一类药物。该类药物选择性的作用于血小板的ADP受体(P2Y1和P2Y12受体),抑制血小板膜ADP受体的表达、结合及其活性,从而有效的抑制了血小板的聚集和血栓的形成。目前应用于临床药物有噻氯匹定、氯吡格雷。还有多个药物正处于临床试验或临床前期实验中。现对ADP受体阻滞剂在抗血小板形成药物中的重要地位、研究进展和开发前景进行综述,为该类药物的研发提供依据。
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| 关 键 词： | 抗血小板药物 P2Y1受体 P2Y12受体 阻滞剂 |
| 文章编号： | 1004-3934(2007)01-0130-04 |
| 修稿时间： | 2006-03-08 |
Advance in Research of ADP Receptor Inhibitors |
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| SHI Fang-niu,XU Wei-ren,ZHANG Shi-jun,WANG Yu-li.Advance in Research of ADP Receptor Inhibitors[J].Advances in Cardiovascular Diseases,2007,28(1):130-133. |
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| Authors: | SHI Fang-niu XU Wei-ren ZHANG Shi-jun WANG Yu-li |
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| Affiliation: | 1. Tianjin Medical University, Tianjin 300070, China; 2. Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China |
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| Abstract: | ADP receptors antagonists are a type of drug that can inhibit thrombosis from binding to ADP receptors. These drugs could combine with ADP receptors selectively and inhibit the expression, conjugation and activity of ADP receptors (P2Y1, P2Y 12) in the platelet membrane, thereby restraining platelet aggregation and thrombosis effectively. Ticlopidine and clopidogrel have now become part of clinical practice. Many other drugs with similar effects are undergoing clinical trials or preclinical experiments. This paper summarizes research developments and offers information on ADP receptors antagonists to provide evidence for further research and development. |
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| Keywords: | antiplatelet drugs P2Y1 receptor P2Y 12 receptor antagonists |
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