Recombinant activated Factor VII as a hemostatic agent in very low birth weight preterms with gastrointestinal hemorrhage and disseminated intravascular coagulation |
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Authors: | Fischer Doris Schloesser Rolf Buxmann Horst Veldman Alex |
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Affiliation: | Department of Pediatrics, Division of Neonatology, J.W. Goethe-University Hospital, Frankfurt, Germany. doris.fischer@kgu.de |
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Abstract: | OBJECTIVE: Acute hemorrhage in preterm infants leads immediately to a life-threatening event because of the small circulating blood volume. The beneficial use of recombinant activated Factor VII (rFVIIa; NovoSeven, NovoNordisk, Gentofte, Denmark) as hemostatic treatment in neonates with hemorrhagic shock has been described. Necrotizing enterocolitis is a challenge in neonatology as the disease represents one of the leading causes of mortality in preterm infants. We report on the use of rFVIIa in very low birth weight (<1500 g), preterms with intestinal hemorrhage, and disseminated intravascular coagulation (DIC). DESIGN: Retrospective analysis of 5 cases. PATIENTS: Five preterm infants
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