肝炎肝硬化患者发生多重耐药菌感染病例危险因素分析

目的：用病例对照研究探讨肝炎肝硬化患者发生多重耐药菌感染的危险因素。方法：选择发生多重耐药菌感染的肝炎肝硬变患者18例作为病例组，发生敏感菌感染的肝炎肝硬变患者91例作为对照组，进行流行病学调查。结果：单因素分析发现院内感染、插管、血清总胆红素、抗生素应用时间为肝炎肝硬变患者发生多重耐菌药感染的可能危险因素。Logistic回归分析表明只有院内感染、抗生素应用时间与发生多重耐药菌感染有关。结论：控制院内感染、合理应用抗生素可以减少肝炎肝硬变患者发生多重耐药菌感染的风险。

Investigation of risk factors for antibiotic multi-resistance bacterial infection in patients with liver cirrhosis by case-control study

Objective:To make an inquiry into the probable risk factors for antibiotic multi-resistance bacterial infection in patients with liver cirrhosis by case-control study.Metheds:18 liver cirrhosis patients with infection of antibiotic multi-resistant bacteria were compared with 91 control cases whose infection were caused by antibiotic sensitive bacteria. Factors such as age, gender, duration of hospital stay, steroid use, intubatton, nosocomial infection, duration of antibiotic treatment before infection, biochemical index of hepatic function were investigated in all patients. Results: A univariable analysis showed that nosocomial infection, intubatton, serum total bilirubin and duration of antibiotic treatment before infection were the risk factors for multi-antibiotic resistance. By multivariable logistic regression analysis, We found only nosocomial infection and duration of antibiotic treatment before infection were the risk factors for antibiotic multi-resistance bacterial infection. Conclusion:Efforts should be emphasized on controlling nosocomial infection and judicious using of antibiotics, which may decrease the risk of antibiotic multi-resistant bacterial infection in patients with liver cirrhosis.