Antiproliferative properties of polyketides isolated from Virola sebifera leaves |
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Authors: | Denny Carina Zacharias Marcela Engelbrecht Ruiz Ana Lúcia Tasca Gois do Carmo E do Amaral Maria Bittrich Volker Kohn Luciana Konecny de Oliveira Sousa Ilza Maria Rodrigues Rodney Alexandre Ferreira de Carvalho João Ernesto Foglio Mary Ann |
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Affiliation: | Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas, P.O. Box 6171, 13083-970, Universidade Estadual de Campinas, UNICAMP, Campinas, SP, Brazil. |
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Abstract: | An activity-guided fractionation of Virola sebifera Aubl. methylene chloride-soluble fraction provided novel 3,5-dihydro-2-(1'-oxo-3'-hexadecenyl)-2-cyclohexen-1-one (3), two known lignans (1, 2) and dehydro hexadecanoyl resorcinol (4). Isolation and purification were conducted with the application of column chromatography and structures were assigned by spetral analysis (1D and 2D NMR, HREIMS). Compounds 1-4 were evaluated for cytotoxic activities against human tumour cell lines UACC62 (melanoma), MCF-7 (breast), NCI 460 (lung, non-small cells), OVCAR03 (ovarian), PC-03 (prostate), HT-29 (colon), 786-0 (renal) and NCI-ADR (breast expressing phenotype multiple drugs resistance) in vitro. The new polyketide (3) showed selectivity against human OVCAR03 and NCI-ADR cell lines, ranging from 2 to 4 microg/mL. |
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Keywords: | Myristicaceae Virola sebifera 3,5‐dihydro‐2‐(1′‐oxo‐3′‐hexadecenyl)‐2‐cyclohexen‐1‐one lignans polyketides antiproliferative activity |
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