骨组织工程研究进展

组织工程学是应用生命科学和工程学的原理及技术，构建、培育活组织，研制生物替代物，以修复或重建组织器官的结构，维持或改善功能的一门新兴学科。目前组织工程学研究的主要问题是：①种子细胞的体内、体外培养；②支架材料的研究与开发；③种子细胞与基质材料相互作用的调控等。骨创伤、肿瘤和炎症等导致的骨缺损是目前骨科临床的常见病和难治病，惟一的方法是通过骨移植进行修复。利用骨组织工程培养的人工骨不仅可修复大面积的骨缺损，而且可按需塑形及大量制备，是一种理想的创伤修复及功能重建的材料。

Progresses in bone tissue engineering

Bone tissure engineering plays an important role in tissure engineering. It typically uses an osteoblasts,artificial extracellular matrix(scaffold),and osteoinductive factors which promote cell attachment,differentiation,and mineralized bone formation. So it contents three problems at least:osteoblasts culture in vivo and in vitro,scaffold studies and regulation factors. Bone defect caused by trauma,tumor and inflammation is a frequent and formidable problem in clinical orthopedics. It appears that artificial bone produced by bone tissure engineering can save the problem well. With the development of tissue engineering,bone tissue engineering is developing rapidly. However,seldom experiments are on human body,and fewer productions of bone tissure engineering are used in clinic.