| Influence of Ehrlich Ascitic Carcinoma on Immune System:Inhibition of Host Response to Thymus-dependent Antigen |
| |
| 作者姓名： | 姜世勃 李文简 |
| |
| 作者单位： | Department of Immunology First Medical College of PLA，Guangzhou，Department of Immunology，First Medical College of PLA，Guangzhou |
| |
| 摘 要： | The response of Ehrlich ascitic carcinoma(EAC)-bearing hosts tothymus-dependent antigen(TDA)was assayed by plaque forming cells(PFC)andhemagglutination(HA)tests.It was found that the number of antibody-formingcells(AFC)and titer of antibody to sheep red blood cells(SRBC)decreased withEAC development.Transfer of normal thymocytes and spleen cells could enhancethe response of the recipient to TDA,but transfer of those from EAC-bearingdonor could not.Normal bone marrow cells plus thymocytes or spleen cells fromEAC-bearing mice,in contrary to the cells from nomal donors,were inefficient inimmunological reconstitution when they were transplanted into lethally irradiatedrecipients.The results suggest that deficiency of host response to TDA might beassociated with the decline of helper cell activity in the thymus and spleen oftumor-bearing mice.
|
Influence of Ehrlich Ascitic Carcinoma on Immune System:Inhibition of Host Response to Thymus-dependent Antigen |
| |
| Jiang Shibo Li Wenjian.Influence of Ehrlich Ascitic Carcinoma on Immune System:Inhibition of Host Response to Thymus-dependent Antigen[J].Journal of Medical Colleges of PLA(China),1987(1). |
| |
| Authors: | Jiang Shibo Li Wenjian |
| |
| Affiliation: | Jiang Shibo Li Wenjian Department of Immunology,First Medical College of PLA,Guangzhou |
| |
| Abstract: | The response of Ehrlich ascitic carcinoma(EAC)-bearing hosts to thymus-dependent antigen(TDA)was assayed by plaque forming cells(PFC)and hemagglutination(HA)tests.It was found that the number of antibody-forming cells(AFC)and titer of antibody to sheep red blood cells(SRBC)decreased with EAC development.Transfer of normal thymocytes and spleen cells could enhance the response of the recipient to TDA,but transfer of those from EAC-bearing donor could not.Normal bone marrow cells plus thymocytes or spleen cells from EAC-bearing mice,in contrary to the cells from nomal donors,were inefficient in immunological reconstitution when they were transplanted into lethally irradiated recipients.The results suggest that deficiency of host response to TDA might be associated with the decline of helper cell activity in the thymus and spleen of tumor-bearing mice. |
| |
| Keywords: | Ehrlich ascitic carcinoma immune system thymus-dependent antigen antibody-forming cells |
| 本文献已被 CNKI 等数据库收录！ |
