| 卡托普利抑制血管紧张素Ⅱ在家兔血管平滑肌细胞引起的钙增加 |
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| 引用本文： | 齐建华,章,鲁,王,军,顾培坤,金正均,王新明.卡托普利抑制血管紧张素Ⅱ在家兔血管平滑肌细胞引起的钙增加[J].中国药理学与毒理学杂志,1996,10(2):151-152. |
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| 作者姓名： | 齐建华 章 鲁 王 军 顾培坤 金正均 王新明 |
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| 作者单位： | [1]上海第二医科大学药理学教研室 [2]中国科学院上海细胞生物学研究所 |
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| 摘 要： |
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| 关 键 词： | 卡托普利 血管紧张素 血管平滑肌 钙 |
| 收稿时间： | 1995-1-14 |
Captopril inhibits angiotensin Ⅱ-induced increase in Ca2+ concentration in rabbit vascular smooth muscle cells |
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| QI Jian-Hua, ZHANG Lu, WANG Jun, GU Pei-Kun, JIN Zheng-Jun, WANG Xin-Ming.Captopril inhibits angiotensin Ⅱ-induced increase in Ca2+ concentration in rabbit vascular smooth muscle cells[J].Chinese Journal of Pharmacology and Toxicology,1996,10(2):151-152. |
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| Authors: | QI Jian-Hua ZHANG Lu WANG Jun GU Pei-Kun JIN Zheng-Jun WANG Xin-Ming |
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| Affiliation: | (Department of Pharmacology, Shanghai Second Medical University, Shanghai 200025; 2. Shanghai Institute of Cell Biology, Chinese Academy of Sciences, Shanghai 200031) |
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| Abstract: | The effect of captopril (Cap) on angiontensinⅡ(AngⅡ)-increased Ca2+ in rabbit aortic smooth muscle cells (ASMC) was examined. Cultured ASMC were loaded with the fluorescent dye Fura 2-AM and cellular free calcium (［Ca2+］i) was determined by using digital image processing technique. AngⅡ induced a concentration-dependent increase in Ca2+］i. Verapamil (0.1-10 μmol·L-1) inhibited AngⅡ-increased ［Ca2+］i, Cap 1-10 but not 0.1 μmol·L-1 decreased ［Ca2+］i response to AngⅡ. These results indicate that Cap inhibits Ang II-induced increase in ［Ca2+］i via voltage-dependent calcium channel, which may be of therapeutic relevance. |
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| Keywords: | Saorta thoracic calcium captopril verapamil angiotensinⅡ |
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