Synthesis of crosslinked nanostructured saccharidic vinyl copolymers and their functionalization |
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Authors: | Vincenzo Bertini Silvana Alfei Barbara Idini Francesco Lucchesini |
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Affiliation: | Dipartimento di Chimica e Tecnologie Farmaceutiche e Alimentari, Università di Genova, Via Brigata Salerno, 13 I-16147 Genova, Italy |
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Abstract: | Saccharidic monomers and a macromonomer were synthesized and copolymerized in the presence of divinylbenzene (DVB) as crosslinker in conditions of separation of phases to give hydrophilic nanostructured sugar-based vinyl copolymers. Appropriate model molecules such as N-benzyl-d-gluconamide for the saccharidic copolymers and 4-(4-chlorobutoxy)benzaldehyde and (E)-4-(4-chloro-2-butenyloxy)benzaldehyde for electrophilic reagents prefiguring possible copper amine oxidase inhibitors allowed identification of conditions for useful monofunctionalizations mainly at the position 2 of the saccharidic units. The examined samples of the nanostructured copolymers from one of the monomers proved to be stable enough to tolerate the functionalization reactions without loss of morphology. |
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Keywords: | Saccharidic copolymers Nanostructured copolymers Functionalization N-Benzyl- smallcaps" >d-gluconamide |
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