2型糖尿病患者糖化血红蛋白和C肽水平与肝功能异常关系分析

目的 探讨2型糖尿病患者血糖控制与肝功能异常的相关性.方法 选择该院内分泌科门诊和住院已经确诊的2型糖尿病患者156例,检测其糖化血红蛋白(HbA1c)、空腹血糖(FPG)、餐后2 h血糖(2 hPG)、空腹C肽(FCP)、餐后2 h C肽(2 hCP)和肝功能,并对检测结果进行比较及统计学处理,对伴肝功能损害情况进行分析.结果 2型糖尿病患者肝损害发生率37.82%;B组(HbA1c>9%)患者的血糖水平、肝功能异常率显著高于A组(HbA1c≤9%),P<0.01;而B组(HbA1c>9%)C肽水平均明显低于A组(HbA1c≤9%).结论 HbA1c可反映糖尿病控制好坏与否,较好地控制血糖是改善2型糖尿病患者肝损害的主要措施.

Relationship between levels of glycosylated hemoglobin and C-peptide and abnormal liver function in patients with type 2 diabetes

Objective To evaluate the correlation between glycemic control and abnormal liver function in type 2 diabetic patients.Methods 156 cases of patient with definite diagnosis of type 2 diabetes from outpatient and inpatient of Department of Endocrinology were enrolled and detected for glycosylated hemoglobin test(HbA1c),fasting blood glucose(FPG),2 h postprandial blood glucose(2 hPG),fasting C-peptide(FCP),2 h postprandial C-peptide(2 hCP) and liver function.The results and the associated liver damage were compared and statistical analyzed.Results The incidence of liver damage in patients with type 2 diabetes was 37.82 %.Blood glucose level and liver function abnormalities in B group(HbA1c>9%) were significantly higher than A group(HbA1c≤9%),P<0.01.C-peptide level in B group(HbA1c>9%) was significantly lower than that in A group(HbA1c≤9%).Conclusion HbA1c might reflect the diabetes control level.Better glycemic control could be the main measure to improve liver damage in patients with type 2 diabetes.