| 藏药唐古特青兰对冠脉结扎大鼠急性心肌缺血的保护作用 |
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| 引用本文： | 刘凤云,王守宝,海平,王洪庆,陈若云,杜冠华.藏药唐古特青兰对冠脉结扎大鼠急性心肌缺血的保护作用[J].青海医学院学报,2011,32(1):35-39. |
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| 作者姓名： | 刘凤云 王守宝 海平 王洪庆 陈若云 杜冠华 |
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| 作者单位： | 1. 青海省心血管病医院中心实验室
2. 中国医学科学院药物研究所 |
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| 摘 要： | 目的 观察藏药唐古特青兰(DtM)水提部分抗大鼠急性心肌缺血作用.方法 采用冠脉结扎致急性心肌缺血模型,观察 DtM 对大鼠心电图ST段移位、心肌梗死范围及血清心肌酶活力的影响.结果 DtM水提液可以显著减少大鼠急性心肌缺血面积(P＜0.05).2.5g生药/kg体重组与模型组相比可以显著降低心肌缺血造成的心电图ST段...
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| 关 键 词： | 唐古特青兰 冠脉结扎 急性心肌缺血 保护 |
PROTECTIVE EFFECTS OF DRACOCEPHALU MTANGUTICUM MAXIM ON ACUTE MYOCARDIAL ISCHEMIA IN CORONARY ARTERY LIGATED RATS |
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| Liu Fengyun,Wang Shoubao,Hai Ping,Wang Hongqing,Chen Ruoyun,Du Guanhua.PROTECTIVE EFFECTS OF DRACOCEPHALU MTANGUTICUM MAXIM ON ACUTE MYOCARDIAL ISCHEMIA IN CORONARY ARTERY LIGATED RATS[J].Journal of Qinghai Medical College,2011,32(1):35-39. |
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| Authors: | Liu Fengyun Wang Shoubao Hai Ping Wang Hongqing Chen Ruoyun Du Guanhua |
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| Affiliation: | Liu Fengyun1,Wang Shoubao2,Hai Ping1,Wang Hongqing2,Chen Ruoyun2,Du Guanhua2 (1 Centralab,Qinghai Cardio-vascular Diseases Vocational Hospital,2 Institute of Materia Medica,Chinese Academy of Medical Sciences) |
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| Abstract: | Objective To observe the protective effects of water-solubility fraction extracted from Dracocephalumtanguticum Maxim（DtM）（traditional Tibetan medicine） on rats with acute myocardial ischemia.Methods The acute myocardial ischemia model was induced by ligation of left anterior descending coronary artery at the distal one third segment in opened chest rats.The Ⅱ-lead electrocardiogram were examined before and after ligation,the infarct area was showed with TTC stain after ligation.Furthermore,the effect of DtM on the above parameters and CK and LDH contents of serum were also studied in comparison with model.Results Compared with model,all groups using different dosage DtM could reduce the area of myocardial infarction（P〈0.05）.Furthermore,The group using 2.5g gruff per kilogram weight dosage of DtM markedly lowered the elevation of S-T segment and the amplitude of T wave in the electrocardiograms of rats,and reduced the LDH contents of serum,no effect was shown in others on the above parameters in comparison with model.Conclusion DtM produced the effect against acute myocardial ischemia in rats. |
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| Keywords: | Dracocephalumtanguticum Maxim Acute myocardial ischemia Coronary artery ligation Protective effect |
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