丹参在斑秃的临床应用及微循环观察

目的观察斑秃的临床分期及微循环变化,探讨其发病机制并寻找新的治疗方法及途径。方法采用血液黏度仪监测56例斑秃患者的6项指标,并分活动期与静止期、中医实症组与虚症组,并与正常对照组比较。再将斑秃患者随机分为丹参治疗亚组(A组)及非丹参治疗亚组(B组),观察两个亚组治疗前、后指标的变化。结果斑秃患者的全血还原黏度(高切与低切)、血浆黏度、红细胞压积及红细胞聚集指数均明显高于正常对照组(P<0．05),而红细胞变形指数则明显低于正常对照组(P<0．05),且以活动期及中医实症者为甚。与治疗前相比,A组治疗后除红细胞变形指数为上升外,其余血液流变学指标均明显下降(P值均<0．05);而B组治疗前、后各指标的差异无显著性(P值均>0．05)。A组的临床痊愈率及有效率均明显优于B组(P<0．05)。结论斑秃患者存在不同程度的血液流变学异常,其发病原因可能与微循环障碍有关。丹参注射液对斑秃具有较好临床疗效。

Application of DanShen for alopecia areata with observations on microcirculation

Objective To observe the changes of alopecia areata in clinical staging and microcirculatory disturbance and to investigate the pathogenetic mechanism to search for a new method of treatment. Methods 6 indices of hemorheology were measured by blood viscometer in 56 Alopecia areata patients. Comparing with the control group, these patients were divided into active stage and silent stage, excessiveness and deficiency groups in view of Traditional Chinese Medicine. And then, the patients groups were again divided into DanShen treated group (group A) and Non-DanShen treated group (group B). The indices of hemorheology in group A and B were recorded before and after treatment. Results The reduced viscosity at high shear (RVHS) and reduced viscosity at low shear (RVLS) of whole blood, hematocrit (HCT), plasma viscosity and degree of aggregation of erythrocyte ( EAI) were much higher than those of the control group (P < 0. 05). Erythrocytic deformation index (EDI) was much lower than that of the control group, especially in the active stage and excessiveness group (P < 0. 05). The indices of hemorheology except EDI were more ameliorable after treatment, but there were no signficant differences between those before and after treatment in group B (P > 0. 05). The cure rates and effective rates of group A were much more superior to those of group B (P < 0. 05). Conclusion DanShen injectio is clinically effective for Alopecia areata which improves the microcirculatory disturbance.