| HPLC法测定盐酸左布比卡因有关物质及对映体纯度 |
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| 引用本文： | 符义刚,李莉娥,李杰,胡先明.HPLC法测定盐酸左布比卡因有关物质及对映体纯度[J].化学与生物工程,2011,28(8):91-94. |
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| 作者姓名： | 符义刚 李莉娥 李杰 胡先明 |
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| 作者单位： | 1. 武汉大学药学院,湖北武汉,430072
2. 宜昌人福药业有限责任公司,湖北宜昌,443005 |
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| 摘 要： | 采用高效液相色谱法,以Dikma Platisil ODS柱测定盐酸左布比卡因有关物质,以研创MCDP手性柱测定盐酸左布比卡因对映体纯度.结果表明,盐酸左布比卡因与其中间体及降解产物之间分离良好;盐酸左布比卡因与其右旋对映体可完全分离(R＞1.5).该方法快速简便、准确可靠,可用于盐酸左布比卡因的质量控制.
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| 关 键 词： | 高效液相色谱法 盐酸左布比卡因 有关物质 对映体纯度 |
Determination of Related Substances and Enantiomer Purity of Levobupivacaine Hydrochloride by HPLC |
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| FU Yi-gang,LI Li-e,LI Jie,HU Xian-ming.Determination of Related Substances and Enantiomer Purity of Levobupivacaine Hydrochloride by HPLC[J].Chemistry & Bioengineering,2011,28(8):91-94. |
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| Authors: | FU Yi-gang LI Li-e LI Jie HU Xian-ming |
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| Affiliation: | FU Yi-gang1,LI Li-e2,LI Jie2,HU Xian-ming1(1.College of Pharmacy,Wuhan University,Wuhan 430072,China,2.Yichang Humanwell Pharmaceutical Co.Ltd.,Yichang 443005,China) |
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| Abstract: | An assay method for the determination of related substances and enantiomer purity of levobupivacaine hydrochloride was established.HPLC Method was used to determine related substances of levobupivacaine hydrochloride on a Dikma Platisil ODS column,while enantiomer purity was inspected on a MCDP chiral column.The results showed that perfect resolution had been achieved among bupivacaine hydrochloride,its related substances and degradated products.The resolution of the two enantiomers was greater than 1.5.The... |
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| Keywords: | HPLC levobupivacaine hydrochloride related substance enantiomer purity |
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