| 2-氨基-6-甲氧基苯并噻唑的梯度控温合成工艺 |
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| 引用本文： | 路露,李国华,李效军.2-氨基-6-甲氧基苯并噻唑的梯度控温合成工艺[J].河北工业大学学报,2011,40(4):29-31. |
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| 作者姓名： | 路露 李国华 李效军 |
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| 作者单位： | 河北工业大学化工学院,天津,300130 |
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| 摘 要： | 对氨基苯甲醚与硫氰酸钠在溴素-醋酸的催化下得到虫荧光素中间体2-氨基-6-甲氧基苯并噻唑,采用梯度控温法将反应时间缩短至5h,优化后反应条件为25℃下反应2h,而后升温至35℃继续反应2h,最后升温至40℃反应1h,反应即达到终点.本研究将反应时间由10h缩短为5h,且采用无毒的硫氰酸钠替代有毒的硫氰酸铵,使得反应更适...
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| 关 键 词： | 对氨基苯甲醚 硫氰酸钠 2-氨基-6-甲氧基苯并噻唑 合成 梯度控温 |
Gradient temperature control on the process synthesis of 2-amino-6-methoxybenzothiazole |
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| LU Lu,LI Guo-hua,LI Xiao-jun.Gradient temperature control on the process synthesis of 2-amino-6-methoxybenzothiazole[J].Journal of Hebei University of Technology,2011,40(4):29-31. |
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| Authors: | LU Lu LI Guo-hua LI Xiao-jun |
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| Affiliation: | LU Lu,LI Guo-hua,LI Xiao-jun(School of Chemical Engineering,Hebei University of Technology,Tianjin 300130,China) |
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| Abstract: | 2-amino-6-methoxybenzothiazole is a key intermediate of dyes,and it is also a key intermediate of Firefly Luciferin.2-amino-6-methoxybenzothiazole was synthesized by cyclization reaction of anisidine and sodium thiocyanate catalyzed by Br2-CH3COOH.Ammonium thiocyanate was substituted by sodium thiocyanate and gradient temperature control was used in this reaction.The reaction time was reduced to 5 h,and ammonium thiocyanate was substituted by sodium thiocyanate.In this way,the reaction is more suitable for ... |
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| Keywords: | anisidine sodium thiocyanate 2-amino-6-methoxybenzothiazole synthesis gradient temperature control |
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