Serum Levels of 25‐Hydroxy‐Vitamin D3 Among Sun‐protected Outdoor Workers in Israel |
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| Authors: | Esther Azizi Felix Pavlotsky Avraham Kudish Pazit Flint Arie Solomon Yehuda Lerman Bernice Oberman Siegal Sadetzki |
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| Affiliation: | 1. Department of Dermatology, The Gertner Institute, Chaim Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Israel;2. Blaustein Institute for Desert Research, Ben‐Gurion University of the Negev, Beer Sheva and Dead Sea & Arava Science Center, Neve Zohar, Israel;3. Department of Cancer & Radiation Epidemiology Unit, The Gertner Institute, Chaim Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Israel;4. Department of Ophthalmology, The Gertner Institute, Chaim Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Israel;5. Department of Epidemiology and Preventive Medicine, Sackler Faculty of Medicine, Tel‐Aviv University, Tel Aviv, Israel |
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| Abstract: | The objective of this study was to evaluate the effect of reduced sun exposure of outdoor workers on vitamin D status using different modalities of sun protection, for primary prevention of skin cancer. 25‐OH‐D3 measurements were performed in two successive winters, 8 (interim) and 20 months after initiation of the study, in three groups of male outdoor workers, enrolled in either a complete, partial or minimal sun protection program. Ambient solar UVB radiation was monitored simultaneously. No intragroup or intergroup differences were observed between the interim‐ and postintervention measurements of mean 25‐OH‐D3, which were close to 30 ng mL?1. Significant risk factors for postintervention 25‐OH‐D3 levels >33.8 ng mL?1 (a surrogate for reduced sun protection) were: previous sunburn episodes (OR 2.5; 95% CI 1.01–6.3; P = 0.05) and younger age (OR 0.92; 95 CI 0.86–0.98; P = 0.009). Outdoor workers of Western, compared with those of Eastern paternal origin had a borderline significant risk (OR 2.4; 95% CI 0.9–6.3; P = 0.07). A borderline significant effect (OR 2.9; 95% CI 0.97–10.1; P = 0.085) was also noted for those in the minimal intervention group. In conclusion, sun protection among outdoor workers following a successful intervention did not suppress mean winter 25‐OH‐D3. |
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