动态磁敏感对比MR灌注成像对脑膜瘤分级的临床价值

目的 探讨不同类型脑膜瘤的动态磁敏感对比MR灌注成像(DSC-PWI)表现,评价DSC-PWI在脑膜瘤分级中的临床价值.方法 对92例经手术及病理证实的不同级别脑膜瘤患者在3.0 T MR扫描仪上术前进行常规MRI检查及DSC-PWI检查.分析其MRI灌注伪彩图像和灌注曲线,分别在肿瘤实质和瘤周水肿部分进行感兴趣区(R...

Dynamic susceptibility contrast perfusion weighted MR imaging in grading of meningioma

Objective：To investigate the feature and clinic value of dynamic susceptibility contrast perfusion weighted MR imaging（DSC-PWI） in different grades of meningioma.Materials and Methods：Total of 92 patients with meningiomas confirmed by operation and pathology underwent conventional MRI and DSC-PWI before resection using a 3.0 T MR unit.The perfusion color images and time-signal intensity curves（TIC） were analyzed.Maximal relative cerebral blood volume（rCBV） of the same ROI within both tumor parenchyma and peritumoral edema were calculated and the data were analyzed with unpaired Student’s t-test analysis.Grading and classifying of meningiomas were according to 2007 WHO classification and grading of tumors.Results：Seventy-eight patients suffered from benign meningiomas and 14 patients with malignat meningiomas.On the rCBV images,the perfusion in parenchyma of benign and malignant meningiomas increased,the perfusion of the peritumoral edema decreased in benign meningioma,and increased in malignant meningioma.The mean maximal rCBV values within the tumor parenchyma of the benign and malignant meningioma were 9.880±3.682 and 11.651±1.597 respectively（t=1.764,P=0.081）.The mean maximal rCBV values within the peritumoral edema were 1.003±0.506 and 2.848±1.182 respectively（t=9.803,P=0.000）.When the TIC were compared after the first pass,the decrease extent of signal intensity within the tumor parenchyma of all meningiomas were larger than the contralateral white mater,the decrease extent of signal intensity within the peritumoral region of benign meningiomas were less than or equal to the contralateral white mater,but in malignant meningiomas show that it is larger than the contralateral white mater.Conclusion：DSC-PWI can provide useful information in grading and subtyping of meningiomas.