脑醒冲剂治疗急性缺血性中风的临床研究

[目的]探讨脑醒冲剂（活血开窍方）治疗急性缺血性中风（AIS）的临床疗效及其药理作用机制。[方法]采用随机对照单盲观察法将200例AIS患者分为2组，其中脑醒冲剂组（治疗组）150例，屁莫通组（对照组）50例。观察脑醒冲剂的临床疗效及其对自由基、血栓素A2（TXA2）与前列环素（PGI2）比值的影响。[结果]治疗组和对照组总有效率分别为91.3%和76.0%，显效率分别为62.0%和46.0%，两组比较差异均有显著性意义（P＜0.01或P＜0.05）。实验指标检测结果显示脑醒冲剂能降低患者血浆脂质过氧化物（LPO）含量，提高超氧化物歧化酶（SOD）、谷光苷肽过氧化物酶（GSH－Px）活性；抑制TXA2生成，促进PGI2合成。[结论]脑醒冲剂治疗急性缺血性中风疗效优于尼莫通；并显示该方能促进自由基清除，减轻自由基损伤，保护脑细胞；能纠正TXA2／PGI2失衡，对抗血栓形成，缓解脑缺血。

Effect of Naoxing Granule in the Treatment of Acute Ischemic Stroke

ive] To observe the therapeutic effect of Naoxing Granule (NG) for acute ischemic stroke (AIS) and to explore its mechanism. [Methods] Single-blind controlled trial was applied. Two hundred cases of AIS were randomly allocated to Group A (n = 150, treated with NG) and Group B (n = 50, treated with nimodipine). Therapeutic effect of NG was observed and plasma free radical levels and the ratio of thromboxane A2 (TXA2) and prostaglandin 2 (PGI2) were detected. [Results] The total effective rate was 91.3%and 76.0% , and the remarkably effective rate was 62.0% and 46.0% in Group A and Group B respectively ( P < 0.01 or 0.05). NG decreased the content of lipid peroxide, increased the activities of superoxide dismutase and glutathione superoxidase, inhibit the production of TXA2 and promote the formation of PGI2. [ Conclusion ] The effect of NG for AIS was superior to nimodipine. Its mechanism may be related to the elimination of free radicals for protecting brain tissue and the correction of TXA2/PGI2 for counteracting the formation of thrombosis and improving cerebral ischemia.