| 对氨基苯乙醇合成新工艺研究 |
| |
| 引用本文： | 何丽蓉,陈国文,沈水珠,张未星. 对氨基苯乙醇合成新工艺研究[J]. 化学世界, 2013, 54(5): 285-288 |
| |
| 作者姓名： | 何丽蓉 陈国文 沈水珠 张未星 |
| |
| 作者单位： | 浙江大学化学工程与生物工程学系,浙江杭州,310027 |
| |
| 摘 要： | 研究了β-苯乙醇为原料,心血管药物的重要中间体对氨基苯乙醇的合成新工艺。通过酯化、硝化、水解、还原四步反应,对氨基苯乙醇的总摩尔收率达到66.4%,含量为99.77%(HPLC法)。产物结构经熔点、GC-MS确证。新工艺具有很大工业化应用价值。
|
| 关 键 词： | 对氨基苯乙醇 还原 硝化 工业化应用 |
Study on the New Synthesis Process of 2-(4-Aminophenyl) Ethanol |
| |
| HE Li-rong,CHEN Guo-wen,SHEN Shui-zhu,ZHANG Wei-xing. Study on the New Synthesis Process of 2-(4-Aminophenyl) Ethanol[J]. Chemical World, 2013, 54(5): 285-288 |
| |
| Authors: | HE Li-rong CHEN Guo-wen SHEN Shui-zhu ZHANG Wei-xing |
| |
| Affiliation: | (Department of Chemical and Biological Engineering,Zhejiang University,Zhejiang Hangzhou 310027,China) |
| |
| Abstract: | The new synthesis process for 2-(4-aminophenyl) ethanol,a key intermediate of cardiovascular drugs,was studied using β-phenylethanol as raw material.Through four step reactions such as esterification,nitrification,hydrolysis,and reduction,the total yield of 2-(4-aminophenyl) ethanol reached 66.4%,and the HPLC purity was 99.77%.The product structure was identified with melting point and GC-MS.The new technology has great industrialized application value. |
| |
| Keywords: | 2-(4-aminophenyl) ethanol reduction nitrification industrialized application |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
