探讨建立江苏地区健康人群血清铁蛋白参考区间

目的调查分析江苏地区健康人群血清铁蛋白水平，探讨江苏地区人群铁蛋白参考区间。 方法回顾性分析24 803例江苏地区2017年1月至12月间送检到我中心使用化学发光免疫分析法检测的体检人群血清铁蛋白结果。将统计人群按照性别、年龄分组，使用SPSS软件进行统计分析，比较各分组的平均铁蛋白水平。 结果江苏地区健康成人血清铁蛋白水平呈偏态分布，不同性别、不同年龄组间血清铁蛋白水平有差异，经统计得出的的男性血清铁蛋白参考区间为：18~30岁(8.30~373.02 ng/ml)、31~40岁(11.88~481.60 ng/ml)、41~50岁(19.34~497.34 ng/ml)、51~65岁(15.05~495.41 ng/ml)、大于65岁(16.01~511.48 ng/ml)，其中18~30岁及30岁以上人群组铁蛋白水平有统计学差异；女性血清铁蛋白参考区间为：18~30岁(7.44~181.76 ng/ml)、31~40岁(5.51~193.91 ng/ml)、41~50岁(4.33~218.88 ng/ml)、51~65岁(7.23~404.37 ng/ml)、大于65岁(7.36~449.67 ng/ml)，其中18~50岁及50岁以上人群组铁蛋白水平有统计学差异。 结论影响铁蛋白浓度的原因除了性别外，铁蛋白水平随年龄递增呈现升高趋势，各地区实验室应建立不同性别及年龄区间的铁蛋白参考区间，从而为临床诊断提供可靠的检测数据。

Discussion on the establishment of a serum ferritin reference range for healthy people in Jiangsu Province

ObjectiveTo investigate the serum ferritin level in healthy people in Jiangsu Province and to explore the reference range of ferritin. MethodsA retrospective analysis of 24 803 cases of serum ferritin in the physical examination population sent to our center from January to December 2017 was made. The population was divided in to groups according to gender and age, and SPSS software was used for statistical analysis and to compare the average ferritin level of each group. ResultsThe serum ferritin level in healthy adults in Jiangsu Province was in a partial distribution, and there were differences between different gender and age groups. The reference serum ferritin levels in male were as follows: ages 18 to 30(8.30~373.02 ng/ml), ages 31 to 40(11.88~481.60 ng/ml), ages 41 to 50 (19.34~497.34 ng/ml), ages 51 to 65(15.05~495.41 ng/ml), ages over 65 years old(16.00~511.48 ng/ml). There were significant ferritin level differences between 18 and 30 years old and over 30 years old. The reference serum ferritin levels in female were as follows: ages 18 to 30(7.44~181.76 ng/ml), ages 31 to 40(5.51~193.91 ng/ml), ages 41 to 50 (4.33~218.88 ng/ml), ages 51 to 65 (7.23~404.37 ng/ml), ages over 65 years old (7.36~449.67 ng/ml). There were significant ferritin level between 18 and 50 years old and over 50 years old. ConclusionIn addition to gender, the level of ferritin is increasing with age. Laboratories in different regions should establish ferritin reference intervals of different genders and ages, so as to provide reliable data for clinical diagnosis.