水相不对称转移氢化*

手性醇和胺是重要的精细化学品，不对称转移氢化是获得这类手性化合物有效、实用的途径之一。在众多的催化剂中，Noyori等发展的手性二胺与过渡金属钌TsDPEN-Ru（TsDPEN = 1，2-二苯基乙二胺）络合物是最有效的催化剂。近年来，随着化学家对绿色化学的日益重视，水作为绿色溶剂被广泛地用作为不对称催化转移氢化的反应介质，具有很高的反应活性、对映选择性和化学选择性。本文综述近年来应用未经修饰和修饰的手性二胺配体与过渡金属钌(cymene)RuCl₂]₂、铑(Cp*)RhCl₂]₂和铱(Cp*)IrCl_2]2的络合物催化的水相中酮、亚胺和活化烯烃的不对称转移氢化的研究进展。

Asymmetric Transfer Hydrogenation in Water

Asymmetric transfer hydrogenation (ATH) has emerged as one of the most practical and powerful pathways to obtain chiral alcohols and amines, which are important fine chemicals. Among the various catalysts for asymmetric transfer hydrogenation, the most efficient one is TsDPEN-Ru TsDPEN=N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine] complex developed by Noyori and coworkers. Recently, with the increasing demanding for green chemistry, water was widely used as green solvent in asymmetric transfer hydrogenation, affording fast reaction rate, high enantioselectivity and good chemoselectivity. This review attempts to present an accounts of the progress made on asymmetric transfer hydrogenation of ketones, imines and activated olefins in water catalyzed by the complexes of unmodified and modified chiral diamines and transition metals, ruthenium(cymene)RuCl₂]_2, rhodium(Cp*)RhCl₂]₂ and iridium(Cp*)IrCl₂]₂. Contents 
1 Introduction 
2 ATH in water with water-soluble chiral diamines ligands 
3 ATH in water with water-insoluble chiral diamines ligands 
4 ATH in water with supported chiral diamines ligands 
5 ATH in water with biomacromolecular hybridized chiral diamine ligands 
6 pH effect and mechanism of ATH of ketones in water 
7 Conclusions and outlook