| 机械刺激对体外骨髓基质干细胞骨向分化作用的研究进展 |
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| 引用本文： | 张鹏,江凌勇,房兵. 机械刺激对体外骨髓基质干细胞骨向分化作用的研究进展[J]. 中国口腔颌面外科杂志, 2012, 10(1): 81-85 |
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| 作者姓名： | 张鹏 江凌勇 房兵 |
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| 作者单位： | 上海交通大学医学院附属第九人民医院·口腔医学院正颌-正畸治疗中心上海市口腔医学重点实验室,上海200011 |
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| 基金项目： | 国家自然科学基金(30901698,10972142);上海市科学技术委员会基金(08411961600)~~ |
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| 摘 要： | 具有多向分化潜能的骨髓基质干细胞(BMSCs)为力学敏感细胞,在体外适当机械刺激作用下,其生物学特性会发生功能性改变,以达到力学刺激的最佳要求,并表现为成骨向分化。此过程涉及多条信号转导通路,但BMSCs如何将机械刺激转变为生物信号,进而指导体内骨形成和改建的确切机制仍不清楚。本文就机械刺激对体外骨髓基质干细胞骨向分化的影响及可能的作用机制等方面的研究进展作一综述。
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| 关 键 词： | 骨髓基质干细胞 机械刺激 骨向分化 |
The roles of mechanical stimulation in osteogenesis of bone mesenchymal stem cells in vitro |
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| ZHANG Peng , JIANG Ling-yong , FANG Bing. The roles of mechanical stimulation in osteogenesis of bone mesenchymal stem cells in vitro[J]. China Journal of Oral and Maxillofacial Surgery, 2012, 10(1): 81-85 |
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| Authors: | ZHANG Peng JIANG Ling-yong FANG Bing |
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| Affiliation: | .(Department of Oral and Maxillofacial Surgery,Ninth People’s Hospital,College of Stomatology,Shanghai Jiao University School of Medicine;Shanghai Key Laboratory of Stomatology.Shanghai 200011,China) |
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| Abstract: | [Summary] Bone mesenchymal stem cells(BMSCs),which are force-sensitive cells,have potentials for differentiation into cells of various types.Their biological characteristics can change functionally according to the appropriate stimulation in vitro,in order to reach the optimal demand of the stimulation.Many signal pathways are involved in osteogenesis.However,how BMSCs transform mechanical stimulation into biological signals and then instruct the bone formation and remodeling is still unclear.The exact mechanism remains to be studied further.This paper summarizes the recent research of effect and possible mechanism that mechanical stimulation acts on bone differentiation of BMSCs in vitro. |
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| Keywords: | Bone mesenchymal stem cells Mechanical stimulation Osteogenesis |
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