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| 电化学疗法与恶性淋巴瘤细胞凋亡与相关基因表达 | |
| 引用本文： | 张文霞,孙慧,王立新,多耀祥,李莉,王志光. 电化学疗法与恶性淋巴瘤细胞凋亡与相关基因表达[J]. 天津医科大学学报, 2001, 7(3): 308-309 |
| 作者姓名： | 张文霞 孙慧 王立新 多耀祥 李莉 王志光 |
| 作者单位： | 1. 天津医科大学生理教研室,300070 2. 肿瘤医院 3. 天津市第一医院 |
| 基金项目： | 天津市自然科学基金课题(编号:993608211) |
| 摘 要： | 目的：探讨电化学疗法（ECT）与肿瘤细胞凋亡的关系。方法：采用Tunel法和免疫组化S－P法，分别检测肿瘤未治疗对照组和ECT组B细胞淋巴瘤组织的细胞凋亡率和p53,bcl-2基因的表达。结果：ECT组肿瘤细胞凋亡率（5．18）显著高于对照组（1．05），p53,bcl-2在ECT组表达分别为80％，25％，在对照组表达分别为15％，90％，ECT组中p53表达与癌细胞凋亡率呈正相关，而bcl-2则与癌细胞凋亡率呈负相关。结论：ECT可诱导癌细胞凋亡，其发生可能与p53和bcl-2基因调控有关。 |
| 关 键 词： | 电化学疗法 细胞凋亡 p53基因 bcl－2基因 恶性淋巴瘤 治疗 |
| 文章编号： | 1006-8147(2001)03-0308-02 |
| 修稿时间： | 2000-11-22 |
ECT and apoptosis and apoptosis- related gene expression in malignant lymphoma |
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| ZHANg Wen-xia,SUN Hui,WANG Li-xin,DUO Yao-xiang,LI Li,WANG Zhi-guang. ECT and apoptosis and apoptosis- related gene expression in malignant lymphoma[J]. Journal of Tianjin Medical University, 2001, 7(3): 308-309 | |
| Authors: | ZHANg Wen-xia SUN Hui WANG Li-xin DUO Yao-xiang LI Li WANG Zhi-guang |
| Affiliation: | ZHANg Wen-xia1,SUN Hui2,WANG Li-xin3,DUO Yao-xiang1,LI Li1,WANG Zhi-guang1 |
| Abstract: | Objective: To study the relationship of ECT and apoptosis of malignant lymphoma.Methods:Using Tunel and immunohisytochemistry S-P method, the apoptotic rate(AR) and expression of p53 and bcl-2 protein of B-lymphoma in ECT and control group were examined.Results: Few apoptotic cell were found in control group(P<0.001), the AR significantly lower than that of ECT. The frequency of expression of p53 and bcl-2 in ECT was 80% and 25%, respectively, while that in control group was 15% and 90%. In ECT, expression of p53 was positively correlated, while bcl-2 negatively correlated with the AR(P<0.001).Conclusion: Apoptosis is induced in ECT which may be related to p53 and bcl-2 gene regulation. |
| Keywords: | ECT Apoptosis p53 gene Bcl-2 gene |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
