| 正交试验法优选氟尿苷二乙酸酯固体脂质纳米粒制备工艺 |
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| 引用本文： | 连佳芳,张三奇,顾宜,方坤泉,奚苗苗,王莉.正交试验法优选氟尿苷二乙酸酯固体脂质纳米粒制备工艺[J].中国药房,2006,17(11):818-820. |
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| 作者姓名： | 连佳芳 张三奇 顾宜 方坤泉 奚苗苗 王莉 |
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| 作者单位： | 1. 第四军医大学西京医院药剂科,西安市,710032;解放军白求恩军医学院药理学教研室,石家庄市,050081
2. 第四军医大学西京医院药剂科,西安市,710032 |
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| 摘 要： | 目的:优选氟尿苷二乙酸酯固体脂质纳米粒(FUDRA-SLN)的工艺条件。方法:以大豆磷脂为载体,采用薄膜超声分散法制备FUDRA-SLN,以包封率、形态为考察指标,设计正交试验优选工艺条件。结果:按最优工艺条件制得的FUDRA-SLN均匀圆整,粒径为(215±83)nm,包封率为98·27%,载药量为8·20%。结论:选择优化的薄膜超声分散工艺制备FUDRA-SLN,包封率及载药量高,适合于实验室制备。
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| 关 键 词： | 正交设计 氟尿苷二乙酸酯 固体脂质纳米粒 包封率 载药量 |
| 文章编号： | 1001-0408(2006)11-0818-03 |
| 收稿时间： | 09 1 2005 12:00AM |
| 修稿时间： | 11 29 2005 12:00AM |
Optimization of the Preparation Techniques of Floxuridinyl Diacetate Solid Lipid Nanoparticles by Orthogonal Test |
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| LIAN Jiafang,ZHANG Sanqi,GU Yi,FANG Kunquan,XI Miaomiao,WANG Li.Optimization of the Preparation Techniques of Floxuridinyl Diacetate Solid Lipid Nanoparticles by Orthogonal Test[J].China Pharmacy,2006,17(11):818-820. |
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| Authors: | LIAN Jiafang ZHANG Sanqi GU Yi FANG Kunquan XI Miaomiao WANG Li |
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| Abstract: | OBJECTIVE:To optimize the preparation techniques for floxuridinyl diacetate solid lipid nanoparticles(FUDRA-SLN).METHODS:The FUDRA-SLN was prepared by film-ultrasound dispersion method with soybean phosˉpholipids as carrier,and the preparation techniques were optimized by means of an orthogonal test design with entrapment efˉficiency and appearance as indexes of investigation.RESULTS:The FUDRA-SLN prepared in the optimized techniques was even and regular in appearances,with particle diameter at(215±83)nm,entrapment efficiency at98.27%and drug loading dosage at8.20%.CONCLUSIONS:FUDRA-SLN prepared by the optimized film-ultrasound dispersion method has a high entrapment efficiency and high drug loading dosage,and this method is suitable for the laboratory preparation. |
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| Keywords: | Orthogonal design Floxuridinyl diacetate Solid lipid nanoparticles Entrapment efficiency Drug loading dosage |
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