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| 中波紫外线照射延长同种皮肤移植存活 | |
| 引用本文： | 张海玉,单玉兴,孙兆黎,王玲,张丹丹. 中波紫外线照射延长同种皮肤移植存活[J]. 吉林大学学报(医学版), 2003, 29(5): 596-598 |
| 作者姓名： | 张海玉 单玉兴 孙兆黎 王玲 张丹丹 |
| 作者单位： | 1. 吉林大学第一医院儿外科,吉林,长春,130021 2. 吉林大学第一医院骨科 3. 吉林大学基础医学院免疫学教研室 4. 吉林大学临床医学一系99级学生 |
| 基金项目： | 国家自然科学基金;39470664; |
| 摘 要： | 目的 :探讨中波紫外线 ( UV- B)照射延长同种皮肤移植存活机制。方法 :雄性 BALB/c小鼠为受体 ,C57BL/6J小鼠为供体 ,建立同种皮肤移植模型 ,观察 UV- B照射同种皮肤移植存活时间 ;采用 3 H- Td R掺入法和流式细胞仪 ( FACS)来检测受体胸腺淋巴细胞增殖反应和脾脏 T细胞亚群变化。结果 :与对照组相比 ,UV- B照射组同种皮肤移植存活时间明显延长 ( P<0 .0 1 ) ;淋巴细胞增殖反应出现延迟 ,CD4+ 和 CD8+ 细胞增高也延迟。结论 :UV- B照射可能通过抑制移植皮肤内抗原递呈细胞 ( APC)的活性 ,使辅助性 T淋巴细胞 ( TH)活化受到抑制 ,从而阻断直接致敏途径 ,使皮肤移植存活时间延长。 |
| 关 键 词： | 皮肤移植 移植,同种 紫外线疗法 |
| 文章编号： | 1671-587X(2003)05-0596-03 |
| 修稿时间： | 2002-08-20 |
Prolongation of Surviving Period of Allogenic Skin Transplantation with Ultraviolet B radiation |
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| Abstract: | Objective:To study on the mechanism of prolonging the living time of allogenic skin transplantation with ultraviolet B radiation. Methods:The allogenic skin transplantation model was established, with male BALB/c mice as recipient and male C 57 BL/6J mice as donors, record the surviving time of allogenic skin transplant with and without ultraviolet B radiation were recorded. The thymocyte proliferation and T cell subgroup variation were analyzed by 3H TdR medley and FACS. Results:The surviving time of allogenic skin transplantation with ultraviolet B radiation was longer than that of the control group( P <0.01). Both the thymocyte proliferation and CD4 +,CD8 + subgroup proliferation were delayed. Conclusions:Ultraviolet B radiation may block the immediate allergy pathway by inhibiting activity of APC in the allogenic skin transplantation and consequently preventing TH cells activation. [ |
| Keywords: | Skin transplantation Transplantation homologous Ultraviolet therapy |
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