| 黄蜀葵花总黄酮对小鼠急性心肌缺血缺氧损伤的保护作用 |
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| 引用本文： | 范丽,袁丽萍,陈志武,马传庚. 黄蜀葵花总黄酮对小鼠急性心肌缺血缺氧损伤的保护作用[J]. 中国药房, 2005, 16(3): 176-178 |
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| 作者姓名： | 范丽 袁丽萍 陈志武 马传庚 |
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| 作者单位： | 安徽医科大学药理学教研室,合肥市,230032 |
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| 摘 要： | 目的 :研究黄蜀葵花总黄酮 (TFA)对小鼠急性心肌缺血、缺氧损伤的保护作用。方法 :采用皮下注射盐酸异丙肾上腺素(Iso)建立小鼠急性心肌缺血模型 ,观察TFA对小鼠ECGⅡ导联异常ST段、T波以及心肌含水量 (MWC)、心肌指数 (MI)的影响 ;采用气管挟闭建立小鼠心肌缺氧模型 ,观察TFA对小鼠心脏耐缺氧能力的影响。结果 :TFA可显著改善Iso诱发小鼠ECGⅡ导联异常的ST段和T波 ,抑制MWC及MI的升高 ,明显延长气管挟闭后小鼠心电持续的时间。结论 :TFA对小鼠急性心肌缺血、缺氧损伤具有保护作用。
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| 关 键 词： | 黄蜀葵花总黄酮 心肌缺血缺氧 异丙肾上腺素 气管挟闭 |
| 文章编号： | 1001-0408(2005)03-0176-03 |
| 修稿时间： | 2004-04-26 |
Protective Effect of Total Flavone of Abelmoschl Manihot L Medic on Acute Myocardial Ischemic - anoxic Injury in Mice |
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| FAN Li,YUAN Liping,CHEN Zhiwu,MA Chuangeng. Protective Effect of Total Flavone of Abelmoschl Manihot L Medic on Acute Myocardial Ischemic - anoxic Injury in Mice[J]. China Pharmacy, 2005, 16(3): 176-178 |
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| Authors: | FAN Li YUAN Liping CHEN Zhiwu MA Chuangeng |
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| Abstract: | OBJECTIVE:To observe the protective effect of total flavone of Abelmoschl Manihot L medic(TFA)on acute myocardial ischemic and anoxic injury in mice.METHODS:Acute myocardial ischemic model induced by subcutaneous injection of Isoproterenol was adopted to observe the effects of TFA on the abnormal ST segment in lead II and T wave on ECG,myˉocardial water content(MWC)and myocardial index(MI);Moreover the effect of TFA on myocardial anoxic tolerance was obˉserved in trachea clamping mice.RESULTS:TFA could remarkably ameliorate the abnormal changes of ECG and significantly inhibit the increase of MWC and MI of model group.It was found that the ECG lasting time was much longer in the groups pretreated with TFA.CONCLUSION:TFA plays a protective role in myocardial ischemia and anoxic injury in mice. |
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| Keywords: | TFA Myocardial ischemic-anoxic injury Isoproterenol Trachea clamping |
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