| 微小RNA对肺癌化疗敏感性的影响 |
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| 引用本文： | 田静,吴海良.微小RNA对肺癌化疗敏感性的影响[J].国际肿瘤学杂志,2014,41(1):44-46. |
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| 作者姓名： | 田静 吴海良 |
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| 作者单位： | 250117济南，山东省肿瘤医院内科五病区 |
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| 基金项目： | 山东省中医药科技发展计划(项目编号：2013-209) |
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| 摘 要： | 研究发现多种微小RNA （miRNA）的异常表达可以影响肺癌细胞对化疗的敏感性,并且一些miRNA的表达可作为预测化疗敏感性和耐药性的生物标志物,包括miR-125、miR-497、miR-21等.目前已经发现一些信号通路参与miRNA对一些肿瘤化疗敏感性的调节,但大量miRNA的调控机制还未明确,仍需深入研究.
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| 关 键 词： | 微RNAs 癌 非小细胞肺 化疗敏感性 |
Effects of microRNAs on sensitivity of chemotherapy in lung cancer |
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| Tian Jing,Wu Hailiang.Effects of microRNAs on sensitivity of chemotherapy in lung cancer[J].Journal of International Oncology,2014,41(1):44-46. |
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| Authors: | Tian Jing Wu Hailiang |
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| Affiliation: | Department of Medicine, Shandong Cancer Hospital, Ji′nan 250117, China |
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| Abstract: | Researches show that abnormal expressions of microRNAs (miRNAs) can affect chemotherapy sensitivity of lung cancer. Moreover, some miRNAs may serve as biomarkers for sensitivity and resistance of chemotherapy, such as miR 125, miR 497, miR 21 and so on. It is found that some signaling pathways involve in the regulation of miRNAs for chemotherapy sensitivity. But a large number of regulatory mechanisms are not yet clear, and need to be further explored. |
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| Keywords: | MicrRNAs Carcinoma non-small-cell lung Chemotherapy sensitivity |
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