| 特拉匹韦中间体的合成 |
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| 引用本文： | 王玉琴. 特拉匹韦中间体的合成[J]. 精细化工中间体, 2013, 0(6): 33-36,55 |
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| 作者姓名： | 王玉琴 |
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| 作者单位： | 常州吉恩化工有限公司,江苏常州213127 |
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| 摘 要： | L-环己基甘氨酸甲酯与吡嗪-2-甲酰氯进行酰胺化反应后水解成(2S)-2-环己基-N-(2-吡嗪基羰基)甘氨酸,再与L-叔亮氨酸甲酯缩合,最后经水解得到特拉匹韦关键中间体(2S)-2-环己基-N-(2-吡嗪基羰基)甘氨酰-3-甲基-L-缬氨酸,总收率68.3%。
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| 关 键 词： | (2S)-2-环己基-N-(2-吡嗪基羰基)甘氨酰-3-甲基-L-缬氨酸 特拉匹韦 中间体 合成 |
Synthesis of an Intermediate of Telaprevir |
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| WANG Yu-qin. Synthesis of an Intermediate of Telaprevir[J]. Fine Chemical Intermediates, 2013, 0(6): 33-36,55 |
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| Authors: | WANG Yu-qin |
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| Affiliation: | WANG Yu-qin (GenChem (Changzhou) Co., Ltd., Changzhou 213127, China) |
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| Abstract: | （ S ）-2- （ （S）-2- Cyclohexyl -2- [ （pyrazine-2-carbonyl） -amino ] -acetylamino ）-3,3-dimethyl-butyric acid, the key intermediate for Telaprevir, was synthesized from L-cyclohexyl glycine methyl ester by reaction with 2-pyrazineearbonyl chloride, followed by hydrolysis, condensation with L-tert-leucine methyl ester, and hydrolysis of the ester. The overall yield of the target product was 68.3%. |
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| Keywords: | （S）-2- （ （S）-2-cyclohexyl-2- [ （pyrazine-2-carbonyl）-amino ]-acetylamino）-3,3 - dimethyl-butyricacid Telaprevir intermediate synthesis |
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