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Roles of the main olfactory and vomeronasal systems in the detection of androstenone in inbred strains of mice |
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| Authors: | Vera V VOZNESSENSKAYA Maria A KLYUCHNIKOVA Charles J WYSOCKI AN Severtzov Institute of Ecology & Evolution RAS Moscow Russia Monell Chemical Senses Center Market Street Philadelphia PA USA |
| Affiliation: | Vera V. VOZNESSENSKAYA~(1*),Maria A. KLYUCHNIKOVA~1,Charles J. WYSOCKI~2 1 A.N. Severtzov Institute of Ecology & Evolution RAS,Moscow 119071,Russia 2 Monell Chemical Senses Center,3500 Market Street,Philadelphia,PA 19104,USA |
| Abstract: | We investigated the role of the main olfactory and accessory olfactory systems (MOS and AOS respectively) in the detection of androstenone. We used the following experimental approaches: behavioral, surgical removal of the vomeronasal organ (VNX) followed by histochemical verification and Fos immunohistochemistry. Using a Y-maze paradigm we estimated sensitivity of NZB/B1NJ and CBA/J mice to androstenone. CBA mice were 2,000-fold more sensitive to androstenone than NZB mice. VNX caused a 4- to 16-fold decre... |
| Keywords: | Olfaction Vomeronasal organ Chemosensory receptors Olfactory behavior Immunohistochemistry |
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