| C57BL/6小鼠胆结石形成中固醇载体蛋白2的mRNA水平和胆固醇饱和指数增高 |
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| 引用本文： | 安国顺,王海梅,巴图乌拉,王俊峰,倪菊华,李月廷,祝学光.C57BL/6小鼠胆结石形成中固醇载体蛋白2的mRNA水平和胆固醇饱和指数增高[J].基础医学与临床,2006,26(10):1108-1111. |
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| 作者姓名： | 安国顺 王海梅 巴图乌拉 王俊峰 倪菊华 李月廷 祝学光 |
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| 作者单位： | 北京大学,医学部,生化与分子生物学系,北京,100083;北京中医药大学,北京中西医结合医院普外科,北京,100039;北京大学,人民医院 普外科,北京,100044 |
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| 摘 要： | 目的观察C57BL/6鼠胆囊结石形成过程中肝固醇载体蛋白2(SCP2)mRNA水平及胆囊胆汁中胆固醇饱和指数的变化。方法C57BL/6鼠20只,分为结石组和对照组。对照组喂普通饲料,结石组采用1%的胆固醇饮食4周;RT-PCR方法检测肝SCP2 mRNA水平的变化;全自动生化仪检测胆脂,并计算胆固醇饱和指数。结果胆囊结石组肝SCP2 mRNA水平显著升高,胆汁胆固醇饱和指数亦显著增加。结论肝SCP2的表达及胆汁CSI的增高呈正相关。
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| 关 键 词： | 固醇载体蛋白2 胆固醇饱和指数 胆石形成 |
| 文章编号： | 1001-6325(2006)10-1108-04 |
| 收稿时间： | 2005-09-08 |
| 修稿时间： | 2006-04-20 |
mRNA of SCP2 and cholesterol saturation index are increased during gallstone formation in C57BL/6 mice |
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| AN Guo-shun,WANG Hai-mei,BATU Wu-la,WANG Jun-feng,NI Juhua,LI Yue-ting,ZHU Xue-guang.mRNA of SCP2 and cholesterol saturation index are increased during gallstone formation in C57BL/6 mice[J].Basic Medical Sciences and Clinics,2006,26(10):1108-1111. |
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| Authors: | AN Guo-shun WANG Hai-mei BATU Wu-la WANG Jun-feng NI Juhua LI Yue-ting ZHU Xue-guang |
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| Abstract: | Objective To analyze the level of hepatic sterol carrier protein 2(SCP2) mRNA and bile cholesterol saturation index(CSI) during gallstone information in C57BL/6 mice.Methods Twenty C57BL/6 mice were divided into control group and gallstone group.The gallstone group mice were fed with lithogenic diet(containing 1% cholesterol) for 4 weeks.The mRNA level of SCP2 in liver tissue was measured by RT-PCR.The content of biliary lipids and CSI was analyzed by Automatic Biochemistry Analyzer.Results The level of SCP2 mRNA and bile CSI were significantly increased in gallstone group.Conclusion A positive correlation between expression of liver(SCP2) and bile CSI was found during gallstone formation. |
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| Keywords: | sterol carrier protein 2(SCP2) cholesterol saturation index(CSI) gallstone formation |
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