| P－糖蛋白在颅脑肿瘤中表达的研究 |
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| 引用本文： | 孙林泉,黄强,周丽英,李晓楠.P－糖蛋白在颅脑肿瘤中表达的研究[J].中华神经外科杂志,1996(2). |
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| 作者姓名： | 孙林泉 黄强 周丽英 李晓楠 |
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| 作者单位： | 苏州医学院附二院神经外科 |
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| 摘 要： | 采用Ｐ－糖蛋白单抗和免疫荧光染色法检测４５例颅脑肿瘤手术标本，Ｐ－糖蛋白阳性表达率如下：原发性胶质瘤１３／２８，脑转移癌１／２，颅骨恶性肿瘤２／２，脑膜瘤、听神经瘤和垂体腺瘤等良性肿瘤Ｏ／１３。在胶质瘤中Ｐ－糖蛋白的表达强度与肿瘤的恶性程度呈正相关。在同一肿瘤中，Ｐ－糖蛋白的分布很不均一，呈明显的异质性。
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| 关 键 词： | 糖蛋白，单克隆抗体，免疫组化，脑肿瘤 |
Expression of P-glycoprotein in human brain tumors |
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| Sun Linquan,Huang Qiang,Zhou Liying,et al..Expression of P-glycoprotein in human brain tumors[J].Chinese Journal of Neurosurgery,1996(2). |
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| Authors: | Sun Linquan Huang Qiang Zhou Liying |
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| Abstract: | We studied the expression of P-glycoprotein in surgically removed 45 cases human brain tumors by indirect immunofluorescent cell surface staining with monoclonal antibody MRK16,which recognizes the P-glycoprotein epitope, In 28 primary glioma specimens,immunostaining for P-glycoprotein were strongly positive in 6 specimens and intermediately positive in 7 specimens.One of the 2 metastatic carcinoma was strongly positive.Expression of P-glycoprotein was also found in one fibrohistocytoma and one recurrent osteogenic sarcoma of the skull.Immunostaining for P-glycoprotein was heterogeneous distribution in the specimen.There was no significant evidence of immunostaining for P-glycoprotein in 7 meningiomas,3 acoustic neurinomas,3 pituitary adenomas,4 normal brain specimens. |
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| Keywords: | P-glycoprotein Monoclonal antibody Immunohistochemistry Brain tumor |
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