| 人类宫颈癌LDH同工酶谱变化的观察 |
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| 引用本文： | 王志洁,刘知惠,伍春梅,黄铁牛. 人类宫颈癌LDH同工酶谱变化的观察[J]. 河北医科大学学报, 1990, 0(3) |
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| 作者姓名： | 王志洁 刘知惠 伍春梅 黄铁牛 |
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| 作者单位： | 北医学院病毒研究所，北医学院病毒研究所，北医学院病毒研究所，中南财经大学 |
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| 摘 要： | 本文报道了20例人类宫颈鳞状上皮癌LDH同工酶谱变化的观察结果。实验发现痛组织LDH总活力为对照正常宫颈组织的8倍,LDH同工酶谱的变化是LDH_2和LDH_3减少,LDH_4和LDH_5增加,即H亚基减少,M亚基增加,除LDH_3减少外,所有变化均具有统计学意义。说明人类宫颈癌组织基因表达的调控发生了变化。
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| 关 键 词： | LDH同工酶谱 宫颈鳞状上皮癌 |
OBSERVATION ON CHANGES OF LDH ISOZYME PATTERNS IN HUMAN CERVICAL CANCER |
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| Wang Zhijie Liu Zhihui Wu Chunei Ninns lnslilufc,Hnbei Medicul collcge Huang Tieniu zhong nan Uniocrsity of Finunce and Economics. OBSERVATION ON CHANGES OF LDH ISOZYME PATTERNS IN HUMAN CERVICAL CANCER[J]. Journal of Hebei Medical University, 1990, 0(3) |
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| Authors: | Wang Zhijie Liu Zhihui Wu Chunei Ninns lnslilufc Hnbei Medicul collcge Huang Tieniu zhong nan Uniocrsity of Finunce Economics |
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| Abstract: | ABSTRACT The paper reports the observation on changes of LDH isozyme patterns in 20 women suffered from cervical squamous epithelial carcinoma. LDH activity in cancer tissues is 8 folds of control normal cervical tissues, both LDH_2 and LDH_3 are decreased, LDH_4 and LDH_5 are increased, thus indicating the decrease in H subunits and increase in M subunits; except the reduction of LDH_3, all changes are statistically significant. From the results, it is suggested that changes of regulation of gene expression occur in the cases of human cervical cancer. |
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| Keywords: | LDH isozyme patterns cervix squamous epithelioma |
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