| 托拉塞米合成研究 |
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| 引用本文： | 赵世明,尚嘉鹏,李倩,罗振福. 托拉塞米合成研究[J]. 精细化工中间体, 2009, 39(6): 29-30 |
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| 作者姓名： | 赵世明 尚嘉鹏 李倩 罗振福 |
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| 作者单位： | 天津药物研究院化学制药研究部,天津,300193;天津理工大学化学与化工工程学院,天津,300384 |
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| 摘 要： | 以4-羟基吡啶为起始原料。依次经磺化、氯化、酰胺化、取代、缩合反应得到成品。总收率为37．9％，并对合成工艺进行了优化，工艺适合于工业化生产。
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| 关 键 词： | 4-羟基吡啶 合成 优化 |
Study on Synthesis of Torasemid |
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| ZHA Shi-ming,SHANG Jia-peng,LI Qian,LUO Zhen-fu. Study on Synthesis of Torasemid[J]. Fine Chemical Intermediates, 2009, 39(6): 29-30 |
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| Authors: | ZHA Shi-ming SHANG Jia-peng LI Qian LUO Zhen-fu |
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| Affiliation: | ZHAO Shi-ming , SHANG Jia-peng , LI Qian , LUO Zhen-fu (1. Chemical Pharmaceutical Research Department, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China; 2. School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, China) |
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| Abstract: | 4 -Hydroxypyridine was converted into torasemid in several steps, i.e. sulfonation, chlorination, acylation, substitution and condensation, in an overal yield of 37.9%. The reaction conditions were optimized and apt to be scaled up. |
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| Keywords: | 4-hydroxypyridine synthesis optimization |
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