α-硫辛酸联合中药沐足治疗糖尿病周围神经病

目的:观察α-硫辛酸联合"动-定序贯八法"指导中药沐足治疗糖尿病性周围神经病变瘀血阻络型患者的临床疗效。方法:根据纳入与排除标准,收集病例70例,将患者随机分为α-硫辛酸联合安慰剂沐足组(对照组)及α-硫辛酸联合中药沐足组(观察组),治疗观察期为2周。评价治疗前后患者的中医证候积分、神经症状体征评分、下肢动脉血流多普勒踝臂指数、腓总神经传导速度,并记录疗程中的不良反应。结果:治疗后观察组患者的中医证候总分、神经症状评分、神经体征评分小于对照组(P<0.05);观察组患者的踝肱(ABI)指数、腓总神经传导速度高于对照组(P<0.05);而在治疗过程中均未出现与使用药物相关的不良反应。结论:α-硫辛酸联合"动-定序贯八法"之活血化瘀法指导下的中药外洗方沐足能改善糖尿病性周围神经病变患者的临床症状和下肢动脉血流情况,可为中医药治疗糖尿病性周围神经病变提供新的方法。

Clinical Effect of DL-thioctic Acid Combined with Traditional Chinese Medicine Foot Massage in Patients with Diabetic Peripheral Neuropathy

Objective: To observe the effect on diabetic peripheral neuropathy of DL-thioctic acid combined with the Chinese medicine foot massage under the guidance of dynamics-immobility-order-succession and eight methods therapy. Method: Seventy patients were enrolled according to the inclusion and exclusion criteria in this study. Then the patients were randomly divided into the control group and the observation group. The patients in both groups received basis treatment and patients in observation group received Chinese medical foot massage for two two-weeks courses. Scores of Chinese medical symptom, neural symptoms and signs were graded before and after treatment. The ankle-brachial index (ABI) in lower extremity arterial blood flow, common peroneal nerve conduction velocity including motor conduction velocity (MCV) and sensory conduction velocity (SCV) were evaluated before and after treatment. The adverse reactions of treatment were carefully monitored in this study. Result: Scores of Chinese medical symptom, neural symptoms and signs in observation group were lower than that in control group after treatment (P<0.05). Scores of ABI, MCV and SCV were significantly higher in observation group as compard with that in control group (P<0.05). No serious adverse reactions were found. Conclusion: DL-thioctic acid combined with Chinese medicine foot massage under the guidance of dynamics-immobility-order-succession and eight methods therapy can improve the clinical symptoms and the lower extremity arterial blood flow in patients with diabetic peripheral neuropathy, which provide a new method for treatment of diabetic peripheral neuropathy using Chinese medicine.