新型降血压药物分子K—252a结构相似物的合成

采用直链型缩醛与 N,N—二甲基—邻—苯二胺偶联,合成了一种环状结构和天然降血压药物分子 K—252a相似的新化合物。本文报导了这种新化合物的全台成过程并讨论了一种新的成环反应机理。

SYNTHESIS OF A NWE COMPOUND H-101 WHICH IS STRUCTURALLY RELATED TO COMPOUND K-252a,THE POTENT INHIBITOR OF PROTEIN KINASE C

This paper described the synthesis of a new compound (6),which is structurally related to natural product K-252a,the potent Inhibitor of Protein Kinase C.The compound (6) was obtained by condesation of N,N′—Dimethyl—o—phenylenediamine (9) with 5,5—Dimethoxy—2—pentanone (14).The probable mechanism of formation of N—glycosidic linkage by new type cylization reaction was also discussed.