可降解自固化类骨磷灰石支架的研究

0引言一直以来,钙磷生物材料如羟基磷灰石(hy-droxyapatite,HA)由于其成份与骨的无机成份相似,具有良好的生物相容性,作为骨修复材料引起了人们广泛的兴趣。磷酸钙骨水泥是一类可在生理条件下自固化的非陶瓷型类HA人工骨材料,这种由磷酸钙骨水泥(calcium phosphate cement,CPC)转变而成的HA,与天然骨磷灰石有类似的组成结构,植入人体后可参与新陈代谢,促进骨组织生长1,2]。一些研究显示,CPC具有成骨活性和生物降解性,在体内被吸收的同时可引导新骨的生成,从而可克服自体骨、磷酸三钙陶瓷因吸收降解过快造成的局部缺陷以及陶瓷型HA长…

Study on Biodegradable Scaffold of Self-hardening Bone-like Apatite

A novel biodegradable bone repair biomaterial of bone-like carbonated apatite with porous structure was prepared by using self-hardening calcium phosphate cement. Cell culture, degradation in simulated body liquid (SBF) and as a carrier for bone morphogenic protein (BMP) controllable releasing experiments were performed to evaluate the biocompatibility, degradation and BMP carrier properties of the porous scaffold. The results reveal that the degradation property of the carbonated apatite is better than hydroxyapatite, the more the content of CO₃^2- in apatite, the faster the degradation of the materials, the cell could attach, proliferate and differentiate on the porous scaffold, indicating that the bone like apatites not only have excellent biocompatibility but are also biodegradable and can be used as carriers for BMP controlling release.