补肾活血胶囊对老年男性原发性骨质疏松症患者生活质量的影响

目的评价补肾活血胶囊对老年男性原发性骨质疏松症（osteoporosis，OP）患者生活质量（quality of life，QOL）的影响，探讨其作用机制。方法老年男性原发性OP患者200例，按随机数字表法分组。治疗组100例以补肾活血胶囊加钙尔奇D口服，对照组100例以福善关加钙尔奇D口服治疗，疗程1年。治疗前后比较两组中医症状积分、生活质量积分（QUALEFFO-41）、腰椎（L2-L4）、左侧股骨颈骨密度（bonemineral density，BMD）、游离睾酮（freetestosterone，FT）、雌二醇（estradiol，E2）。结果治疗后两组症状积分、生活质量积分，治疗组FT、E2均明显改善（P〈0．05，P〈0．01），治疗组疗效优于对照组（P〈0．05，P〈0．01）。治疗后两组腰椎（L2-L4）、左侧股骨颈BMD均有所提高（P〈0．05），但两组比较，差异无统计学意义（P〉0．05）。结论补肾活血胶囊能改善老年男性原发性OP患者生活质量，考虑与其改善BMD、调节性激素水平相关。

Effect of Busheng Huoxue Capsule on the Quality of Life of Primary Osteoporosis Senile Males

Objective To investigate the effect of Busheng Huoxue Capsule （BHC） on the quality of life （QOL） in senile male osteoporosis （OP） patients, and to explore its mechanisms. Methods Totally 200 senile primary OP patients were randomly assigned to two groups according to random digit table meth- od, 100 in each group. Patients in the treatment group took BHC plus caltrate-D （600 mg CaCO3）, while those in the control group took alendronate （70 mg per week） plus caltrate-D. The therapeutic course was 12 months for all. Chinese medical symptom score and quality of life （QUALEFFO-41）score, bone mineral density （BMD） of lumbar vertebra （L2 -L4） and left femoral neck were compared between the two groups before and after treatment. Serum free testosterone （F-r） and estradiol （E2） were also measured. Results Chinese medical symptom scores and QUALEFFO-41 scores, serum FT and E2 levels increased in the two groups after treatment （P 〈0.05, P 〈0.01 ）. The therapeutic effect was superior in the treatment group （P 〈 0.05, P 〈 0.01 ）. After treatment the BMD of lumbar vertebra （L2 - L4） and the left femoral neck were somewhat improved （P 〈0.05）, but with no statistical difference between the two groups （P 〉0.05）. Con- clusion BHC could effectively improve the QOL of senile male OP patients, which might be correlated with elevating the BMD levels and regulating the levels of sex hormones.