Y染色体长臂异染色质区延长对辅助生殖妊娠结局和新生儿健康情况的影响

目的探讨Y染色体长臂异染色质区延长(Yqh+)对体外受精/卵胞浆内单精子注射-胚胎移植(IVF/ICSI-ET)妊娠结局和新生儿健康情况的影响。方法采用单中心回顾性研究,收集2014年1月至2017年12月期间在西北妇女儿童医院辅助生殖中心行IVF/ICSI-ET助孕的不育症患者为研究对象,根据Y染色体核型分析结果分为Yqh+组和对照组。又根据男方精液分析结果分别行IVF或ICSI人工授精,比较IVF周期和ICSI周期中Yqh+组和对照组的妊娠结局和新生儿健康情况。结果研究共纳入1 705对不育夫妇,其中Yqh+组67例,对照组1 638例。(1)在IVF治疗周期中,Yqh+组和对照组患者一般资料比较无显著性差异(P>0.05)。新鲜移植周期中,Yqh+组的临床妊娠率、活产率略低于对照组,但均无显著性差异(P>0.05);Yqh+组的异位妊娠率显著高于对照组(11.11%vs. 1.63%,P=0.04);两组的新生儿Apgar评分、出生缺陷率和男婴出生率比较亦均无显著性差异(P>0.05)。(2)在ICSI治疗周期中,两组患者的一般资料比较无显著性差异(P>0...

Influence of heterochromatin extension of long arm of Y chromosome(Yqh+)on reproductive outcome and neonatal health in IVF/ICSI-ET

Objective:To investigate the influence of heterochromatin extension of long arm of Y chromosome(Yqh+)on reproductive outcome and neonatal health in IVF/ICSI-ET.Methods:The data of the patients undergone IVF/ICSI-ET in Assisted Reproduction Center of Northwest Women’s &Children’s Hospital from January 2014 to December 2017 were retrospectively analyzed.The patients were divided into Yqh+group and control group according to Y chromosome karyotype analysis.IVF or ICSI insemination method was selected according to the results of semen analysis.IVF/ICSI-ET outcomes and neonatal health were compared between the two groups.Results:A total of 1705 infertile couples were included in the study,including 67 in the Yqh+ group and 1638 in the control group.(1)In IVF cycles,there is no significant difference in general information between Yqh+ group and control groups(P>0.05).After fresh embryo transfer,clinical pregnancy rate,and live birth rate were slightly lower in Yqh+group,but there was no statistical significance(P>0.05).Ectopic pregnancy rate in Yqh+group was significantly higher than that in control group(11.11%vs.1.63%,P=0.04).There was no significant difference in Apgar score,birth defect rate and male birth ratio in neonates between the two groups(P>0.05).(2)In ICSI cycles,there was no significant difference in general information between the two groups(P>0.05).There was no significant difference in the outcomes of pregnancy including clinical pregnancy rate,live birth rate and neonatal status(P>0.05).Conclusions:Yqh+ has no significant effect on IVF/ICSI-ET pregnancy outcome and neonatal health.Whether Yqh+ can increase the risk of ectopic pregnancy in IVF fresh transfer cycle needs to be studied in a larger sample size.