| 氟伐他汀对心力衰竭患者血清可溶性细胞黏附分子的影响 |
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| 引用本文： | 李争,高宪玺,王宝岭,朱卉,黄喆,吴云涛,郑晓明. 氟伐他汀对心力衰竭患者血清可溶性细胞黏附分子的影响[J]. 临床心血管病杂志, 2009, 25(7) |
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| 作者姓名： | 李争 高宪玺 王宝岭 朱卉 黄喆 吴云涛 郑晓明 |
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| 作者单位： | 华北煤炭医学院附属唐山市中医院心内科,河北唐山,063000;华北煤炭医学院附属开滦医院心内科 |
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| 摘 要： | 目的:观察氟伐他汀短期治疗对充血性心力衰竭(congestive heart failure,CHF)患者血清中可溶性细胞间黏附分子-1(sICAM-1)、可溶性血管细胞黏附分子-1(sVCAM-1)、可溶性选择素E(sE- selectin)、可溶性选择素P(sP- selectin)和可溶性选择素L(sL- selectin)水平的影响,探讨氟伐他汀对CHF的治疗作用.方法:将70例CHF患者随机分为常规治疗组和干预组(氟伐他汀组).正常对照组20例.采用酶联免疫吸附法(ELISA)测定其治疗前后血清中sICAM-1、sVCAM-1、sE- selectin、sP- selectin和sL- selectin水平.结果:血清可溶性细胞黏附分子(soluble cell adhesion molecules ,sCAM)水平在心功能Ⅳ级明显高于心功能Ⅱ、Ⅲ级患者,而心功能Ⅱ、Ⅲ级之间比较差异无统计学意义,心功能Ⅱ-Ⅳ级的患者sCAM水平均高于正常对照组(P<0.05或P<0.01).常规治疗组和干预组治疗后血清sCAM水平均较治疗前有显著下降(P<0.05或P<0.01),但干预组较常规治疗组仅sVCAM-1和sE- selectin下降水平显著(P<0.05),余各血清sCAM水平组间比较差异无统计学意义(P>0.05).结论:CHF患者血清sCAM水平下降主要与心功能改善相关,在CHF常规治疗的基础上短期加用氟伐他汀治疗能降低sVCAM-1和sE-selectin水平.
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| 关 键 词： | 心力衰竭 氟伐他汀 细胞黏附分子 |
Effects of fluvastatin on serum soluble cell adhesion molecule in patients with heart failure |
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| LI Zheng,GAO Xianxi,WANG Baoling,ZHU Hui,HUANG Zhe,WU Yuntao,ZHENG Xiaoming. Effects of fluvastatin on serum soluble cell adhesion molecule in patients with heart failure[J]. Journal of Clinical Cardiology, 2009, 25(7) |
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| Authors: | LI Zheng GAO Xianxi WANG Baoling ZHU Hui HUANG Zhe WU Yuntao ZHENG Xiaoming |
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| Affiliation: | 1Department of Cardiology;Chinese medicine Hospital;North China Coal Medical University;Tangshan;063000;China;2Department of Cardiology;Kailuan Limited Liability Company Hospital;North China Coal Medical University |
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| Abstract: | Objective:To observe the effects of short-term treatment of fluvastatin on serum soluble intercellular adhesion molecule-1(sICAM-1),soluble vascular cell adhesion molecule-1(sVCAM-1),soluble E-selectin(sE-selectin),soluble P-selectin(sP-selectin)and soluble L-selectin(sL-selectin)in patients with congestive heart failure(CHF),and investigate the effects of fluvastatin on the treatment of congestive heart failure.Methods:70 CHF patients were randomly divided into conventional treatment group and intervention... |
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| Keywords: | heart failure fluvastatin cell adhesion molecule |
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