关于精细化工中间体色谱指纹图谱的思考

建议借鉴中药指纹图谱的经验，以杂质组学的研究方式，建立精细化工中间体的色谱指纹图谱，将其作为控制中间体质量的一个关键指标。阐述了色谱指纹图谱在中间体的研发、生产、贸易等各环节的重要地位，指出指纹图谱是发展中国精细化工的有效保障。探讨了建立中间体色谱指纹图谱的可行性，并介绍了建立中间体指纹图谱的步骤和技术要素。

The Thinking of Chromatographic Fingerprints of Fine Chemical Intermediates

It has been suggested that chromatographic fingerprints of fine chemical intermediates should be established by using the experience of fingerprint of traditional chinese medicine and the methodology of impuritomics, which was regarded as a key technique for quality control. The important significance of the chromatographic fingerprint for research, development, manufacture and trade of intermediates was presented. It was indicated that the fingerprint would become the powerful support for the progress of fine chemicals in China. The feasibility of establishment of chromatographic fingerprints of intermediates was discussed, as well as the general procedures and the essential techniques for the strategy introduced.