| 具有免疫刺激活性的非甲基化寡核苷酸链的研究进展 |
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| 引用本文： | 郑梅珍,蒋建伟. 具有免疫刺激活性的非甲基化寡核苷酸链的研究进展[J]. 生物化学与生物物理进展, 2003, 30(2): 190-193 |
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| 作者姓名： | 郑梅珍 蒋建伟 |
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| 作者单位： | 暨南大学医学院生化教研室,广州,510632 |
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| 基金项目： | 广东省自然科学基金资助项目(000754). |
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| 摘 要： | 富含非甲基化碱基CG的寡核苷酸链（CpG-oligodeoxynucleotides，CpG-ODN），具有免疫刺激活性.其骨架及侧翼核苷酸序列决定CpG-ODN免疫效应的强度及特异性.最近研究发现，通过对CpG-ODN中核苷酸上的基团进行化学修饰，或改变侧翼核苷酸序列均能影响CpG-ODN的免疫活性、种属及细胞特异性.这对CpG-ODN的深入研究和应用具有一定的指导价值.
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| 关 键 词： | CpG-ODN，化学修饰，免疫刺激效应 |
| 收稿时间： | 2002-10-24 |
| 修稿时间： | 2002-10-24 |
Progress in Unmethylated Immunostimulatory Oligodeoxynucletides |
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| ZHENG Mei-Zhen and JIANG Jian-Wei. Progress in Unmethylated Immunostimulatory Oligodeoxynucletides[J]. Progress In Biochemistry and Biophysics, 2003, 30(2): 190-193 |
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| Authors: | ZHENG Mei-Zhen and JIANG Jian-Wei |
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| Affiliation: | Department of Chemistry, Medical College of Jinan University, Guangzhou 510632, China;Department of Chemistry, Medical College of Jinan University, Guangzhou 510632, China |
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| Abstract: | Unmethylated CG-rich oligodeoxynucletides are exhibiting several immunological effects. The backbone and the flanking sequences of CpG-ODN decide the potence and specificity of its immunostimulatory effects. Chemical modifications have been systematically in corporated into CpG-ODN and the resulting modified compounds have been studied for immunostimulatory activity,the researches show that they have strong effect on species and cells'speciality, which offer the instruction for the design of CpG-ODN. |
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| Keywords: | CpG-ODN chemical modification immunostimulatory effect |
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