| 中长期模拟失重大鼠骨骼肌线粒体钙含量和肌浆网Ca~（2＋）－ATP酶活性变化 |
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| 引用本文： | 孙亚志,黄丽昀,张谦,杨光华,张敏. 中长期模拟失重大鼠骨骼肌线粒体钙含量和肌浆网Ca~（2＋）－ATP酶活性变化[J]. 航天医学与医学工程, 1996, 0(3) |
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| 作者姓名： | 孙亚志 黄丽昀 张谦 杨光华 张敏 |
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| 作者单位： | 航天医学工程研究所，北京医科大学病理生理教研室 |
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| 摘 要： | 为探讨失重对肌肉功能的影响，观察了中长期模拟失重时大鼠骨骼肌细胞内Ｃａ２＋转运功能变化，测定了比目鱼肌、腓肠肌线粒体钙含量和肌浆网（ＳＲ）Ｃａ２＋－ＡＴＰａｓｅ活性。结果是悬吊１５、３０ｄ大鼠比目鱼肌和腓肠肌线粒体Ｃａ＋２含量增加，肌浆网Ｃａ２＋－ＡＴＰ酶活性降低，说明中长期模拟失重肌细胞内Ｃａ２＋转运功能发生了改变，这可能是影响肌肉收缩特性的因素之一。
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| 关 键 词： | 模拟失重 肌收缩 线粒体 肌浆网Ca~（2＋）-ATP酶活性 肌浆网 |
Changes of Ca 2+ in Mitochondria and Ca 2+ -ATPase Activity in Sarcoplasmic Reticulum (SR) in Rat after Simulated Weightlessness. |
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| SUN Yazhi,[ Institute of Space Medico-Engineering,Beijing, China] HUANG Liyun,ZHANG Qian,YANG Guanghua,ZHANG Min.. Changes of Ca 2+ in Mitochondria and Ca 2+ -ATPase Activity in Sarcoplasmic Reticulum (SR) in Rat after Simulated Weightlessness.[J]. Space Medicine & Medical Engineering, 1996, 0(3) |
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| Authors: | SUN Yazhi [ Institute of Space Medico-Engineering Beijing China] HUANG Liyun ZHANG Qian YANG Guanghua ZHANG Min. |
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| Affiliation: | SUN Yazhi,[ Institute of Space Medico-Engineering,Beijing,100094 China] HUANG Liyun,ZHANG Qian,YANG Guanghua,ZHANG Min. |
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| Abstract: | In order to observe changes of Ca 2+ -transport in skeletal muscle during simulated weightlessness Ca 2+ content in mitochondria and (SR)Ca 2+ -ATPase activity in SR were determined before and after simulated weightlessness. The results showed that mitochondriaCa 2+ increased and (SR)Ca 2+ -ATPase activity decreased. This indicated that cellular calcuim transport function was changed. This change may be one of the important factors causing the decrease of muscular contractive function in simulated weightlessness. |
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| Keywords: | weightlessness simulation muscle contraction mitochondria Ca 2+ -ATPase activity of sarcoplasmic reticulum sarcoplasmic reticulum |
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