相转移催化合成邻乙氧基苯酚技术研究

研究了以聚乙二醇(PEG-400)作为相转移催化剂,由邻苯二酚(C6H6O2)与溴乙烷(C2H5Br)为主要原料合成邻乙氧基苯酚(C8H10O2)工艺。以邻乙氧基苯酚的收率为考察指标,考察了反应温度、反应时间、原料物质的量比和催化剂用量(以邻苯二酚的质量为计算依据)等对反应收率的影响,通过正交实验以及单因素实验,建立PEG相转移催化条件下合成邻乙氧基苯酚的适宜工艺条件即:n(C6H6O2)∶n(NaOH)∶n(C2H5Br)=1∶1.2∶1.2,反应温度为68℃,反应时间为6 h,催化剂用量为2%;该反应条件下,产品邻乙氧基苯酚收率65%。以PEG-400为相转移催化剂合成邻乙氧基苯酚的方法工艺成本低、污染小、操作简单易行,适应于工业化生产。

Study on Phase-transfer-catalyzed Synthesis of o-ethoxyphenol

Using polyethylene glycol （ PEG - 400） as phase transfer catalyst, catechol （ C6 H6O2 ） and ethyl bromide as main material, the process of o - ethoxyphenol systhesis are studied. With the yield of o - ethoxyphenod as the index,the effects of reaction temperature, reaction time, molar ratios of the materials and amount of catalyst （ based on the weight of eatechol） on the yield are investigated. The suitable tech- nological conditions of the synthesis of o - ethoxyphenol under the catalyst PEG through orthogonal experi- ments and single factor experiments are determined ： n （ C6 H6O2 ） ： n（ NaOH ） ： n （ C2 H5 Br） = 1 ： 1.2 ： 1.2, the reaction temperature is 65 ℃, reaction time is 6 h, amount of catalyst is 2 %, the yield of o - ethoxyphenol reaches 65%. The process for the synthesis of o - ethoxyphenol under the catalyst PEG is of low cost, little pollution, easy and suitable for the industrial manufacture.