江苏省扬州地区胃癌组织中EB病毒感染与p53蛋白表达的相关性

目的探讨Epstein-Barr病毒(EBV)感染与p53蛋白表达异常在扬州地区胃癌发生发展中的作用及其相关性。方法采用原位杂交法检测胃癌石蜡标本中EB病毒编码的小RNA(EBER1),免疫组化检测胃癌组织中p53蛋白的表达情况。结果 96例胃癌组织中有15例呈EBER1阳性,有明显淋巴细胞浸润的11例,均为管状腺癌。EB病毒阳性胃癌(E-BVaGCs)组织中p53蛋白表达显著高于EB病毒阴性胃癌(EBVnGCs)组织。结论 EBV感染与本地区胃癌的发生有一定的相关性,癌间质中大量淋巴细胞浸润可能是EB病毒感染的重要病理学特征。胃癌组织中EBV感染与p53蛋白的异常表达密切相关。

Epstein- Barr virus infection in gastric carcinoma with p53 protein expression in Yangzhou region

Objective To explore Epstein-Barr virus(EBV) infection and abnormal expression of p53 protein in Yangzhou region of gastric cancer development and its relevance.Methods In situ hybridization was used to examine small RNA(EBER1) from EB virus of gastric cancer tissues and the immunohistochemical detection of gastric carcinoma p53 protein expression.Results In 96 patients with gastric carcinoma,15 cases were EBER1 positive,significant lymphocyte infiltration in 11 cases,and all tubular adenocarcinoma.EB virus-positive gastric cancer(EBVaGCs) p53 protein expression in tissues was significantly higher than the EB virus-negative gastric cancer(EBVnGCs) tissue.Conclusion EBV infection and the incidence of gastric cancer in this region has some relevance.Interstitial infiltration of lymphocytes in the large number of EB virus infection in cancer may be an important pathological feature.EBV infection and gastric cancer in the abnormal expression of p53 protein is closely related.