| 结缔组织生长因子与肝纤维化关系的研究进展 |
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| 引用本文： | 贾玉杰. 结缔组织生长因子与肝纤维化关系的研究进展[J]. 大连医科大学学报, 2014, 36(2): 103-109 |
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| 作者姓名： | 贾玉杰 |
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| 作者单位： | 大连医科大学 基础医学院 病理生理学教研室，辽宁 大连 116044 |
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| 基金项目： | 基金项目：辽宁省自然科学基金资助项目（201102055）；辽宁省教育厅资助项目（2009A190） |
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| 摘 要： | 肝纤维化的形成是一个多因素、多细胞参与的复杂过程，近来研究发现，结缔组织生长因子对促进纤维化的发生发展起正调节作用。结缔组织生长因子是一种多功能的分泌性多肽，可以调节细胞增殖、分化以及黏附等生物学活性，在肝组织损伤修复、细胞外基质合成、临床上肝纤维化的诊断及治疗等方面发挥重要作用。
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| 关 键 词： | 结缔组织生长因子 肝纤维化 细胞外基质 肝星状细胞 |
| 收稿时间： | 2014-02-28 |
| 修稿时间： | 2014-03-01 |
Research progress on the relationship between connective tissue growth factor and hepatic fibrosis |
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| JIA Yu-jie. Research progress on the relationship between connective tissue growth factor and hepatic fibrosis[J]. Journal of Dalian Medical University, 2014, 36(2): 103-109 |
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| Authors: | JIA Yu-jie |
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| Affiliation: | Department of Pathophysiology, Basic Medical College, Dalian Medical University, Dalian 116044, China |
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| Abstract: | The formation of hepatic fibrosis is a complicated process involving multiple factors and cells .It has been found form recent research that connective tissue growth factor plays a positive regulatory role in promoting the occurrence and development of hepatic fibrosis .Connective tissue growth factor belongs to a family of secreting polypeptide , which can regulate cell proliferation , differentiation and adherence , etc.It also plays very important roles in hepatic tissue repair , ex-tracellular matrix synthesis , diagnosis and treatment of hepatic fibrosis in clinical settings , etc. |
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| Keywords: | connective tissue growth factor hepatic fibrosis extra cellular matrix hepatic stellate cells |
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